ReviewPharmaceutical research2004
Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders.
Review in Pharmaceutical research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 114 citations in OpenAlex.
- An Integrative Approach to the Current Treatment of HIV-Associated Neurocognitive Disorders and the Implementation of Leukemia Inhibitor Factor as a Mediator of Neurocognitive Preservation.Life (Basel, Switzerland) · 2023Review
- Recent Advances in Understanding the Structural and Functional Evolution of FtsH Proteases.Frontiers in plant science · 2022Review
- Modulation of the Blood-Brain Barrier for Drug Delivery to Brain.Pharmaceutics · 2021Review
- The Interplay of ABC Transporters in Aβ Translocation and Cholesterol Metabolism: Implicating Their Roles in Alzheimer's Disease.Molecular neurobiology · 2021Review
- Editorial: Organization and Functional Properties of the Blood-Brain Barrier.Frontiers in physiology · 2021Article
- Nrf2 overexpression protects against paraquat-induced A549 cell injury primarily by upregulating P-glycoprotein and reducing intracellular paraquat accumulation.Experimental and therapeutic medicine · 2019Article
- NRDR inhibits estradiol synthesis and is associated with changes in reproductive traits in pigs.Molecular reproduction and development · 2019Article
- A Conformationally Gated Model of Methadone and Loperamide Transport by P-Glycoprotein.Journal of pharmaceutical sciences · 2018Article
- Does G2677T Polymorphism of the MDR1 Gene Make a Difference in the Therapeutic Response to Paroxetine in Depressed Patients in a Slovakian Population?Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Insights Into the Molecular Mechanism of Triptan Transport by P-glycoprotein.Journal of pharmaceutical sciences · 2017Article
- Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model.Biochimica et biophysica acta · 2016Article
- Glial regulation of the blood-brain barrier in health and disease.Seminars in immunopathology · 2015Review
- P-Glycoprotein Transport of Neurotoxic Pesticides.The Journal of pharmacology and experimental therapeutics · 2015Article
- Drug access to the central nervous system in Alzheimer's disease: preclinical and clinical insights.Pharmaceutical research · 2015Review
- Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery.BioMed research international · 2015Review
- The impact of sustained and intermittent docetaxel chemotherapy regimens on cognition and neural morphology in healthy mice.Psychopharmacology · 2014Article
- Absence of P-glycoprotein transport in the pharmacokinetics and toxicity of the herbicide paraquat.The Journal of pharmacology and experimental therapeutics · 2014Article
- Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice.Particle and fibre toxicology · 2013Article
- Glutathione metabolism and Parkinson's disease.Free radical biology & medicine · 2013Review
- Utility of CSF in translational neuroscience.Journal of pharmacokinetics and pharmacodynamics · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of membrane drug transport systems in the central nervous system plays an important role in the brain disposition and efficacy of many pharmacological agents used in the treatment of neurological disorders such as neoplasia, epilepsy, and HIV-associated dementia. Of particular interest is P-glycoprotein, a membrane-associated, energy-dependent, efflux transporter that confers the multidrug resistance phenotype to many cells by extruding a broad range of xenobiotics from the cell, resulting in poor clinical outcomes. In addition, the expression pattern of P-glycoprotein has recently been suggested to play a key role in the etiology and pathogenesis of certain diseases such as Alzheimer's and Parkinson's diseases. This review will focus on the cellular localization, molecular expression, and functional activity of P-glycoprotein in several compartments of the central nervous system and address its relevance in the pathogenesis and pharmacological treatment of neurological disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.