ArticleMolecular vision2004
Contribution of Kir4.1 to the mouse electroretinogram.
Article in Molecular vision, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Diuretic inhibition of experimental myopia implicates retinal ion-driven efflux in the regulation of ocular growth.Frontiers in medicine · 2026Article
- Effects of Selected Antioxidants on Electroretinography in Rodent Diabetic Retinopathy.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Use of an alternating current amplifier when recording the ERG c-wave to evaluate the function of retinal pigment epithelial cells in rats.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- An unusual inherited electroretinogram feature with an exaggerated negative component in dogs.Veterinary ophthalmology · 2022Article
- A Splicing Mutation inInternational journal of molecular sciences · 2022Article
- Noninvasive Electroretinographic Procedures for the Study of the Mouse Retina.Current protocols in mouse biology · 2018Article
- Contribution of GABAa, GABAc and glycine receptors to rat dark-adapted oscillatory potentials in the time and frequency domain.Oncotarget · 2017Article
- Abnormal Electroretinogram after Kir7.1 Channel Suppression Suggests Role in Retinal Electrophysiology.Scientific reports · 2017Article
- Improved retinal function in RCS rats after suppressing the over-activation of mGluR5.Scientific reports · 2017Article
- Early Functional and Morphologic Abnormalities in the Diabetic Nyxnob Mouse Retina.Investigative ophthalmology & visual science · 2016Article
- Early retinal pigment epithelium dysfunction is concomitant with hyperglycemia in mouse models of type 1 and type 2 diabetes.Journal of neurophysiology · 2015Article
- Identification of a new mutant allele, Grm6(nob7), for complete congenital stationary night blindness.Visual neuroscience · 2015Article
- Mouse b-wave mutants.Documenta ophthalmologica. Advances in ophthalmology · 2014Review
- Response properties of slow PIII in the Large (vls) mutant.Documenta ophthalmologica. Advances in ophthalmology · 2012Article
- Exclusion of aldose reductase as a mediator of ERG deficits in a mouse model of diabetic eye disease.Visual neuroscience · 2012Article
- Altered electroretinograms in patients with KCNJ10 mutations and EAST syndrome.The Journal of physiology · 2011Article
- Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome.Journal of the American Society of Nephrology : JASN · 2010Article
- Molecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10).The Journal of biological chemistry · 2010Article
- Light-evoked responses of the retinal pigment epithelium: changes accompanying photoreceptor loss in the mouse.Journal of neurophysiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
purposeThe electroretinogram (ERG) represents the combination of several distinct cellular processes and conductances. Here, we define the contribution that K+ conductance through Kir4.1 channels makes to the mouse ERG.
methodsTo obtain mice expressing different levels of Kir4.1, we mated Kir4.1+/- mice and used PCR to identify Kir4.1+/- and Kir4.1+/+ littermates. In addition, we mated Kir4.1+/- males with females homozygous for the nob (no b-wave) defect, which eliminates post-receptoral contributions to the ERG. After overnight dark adaptation, mice were anesthetized and ERGs were recorded to 7 min stimuli, to focus on slow ERG components, or to strobe flash stimuli, to examine earlier ERG components.
resultsThe amplitudes of the ERG c-wave and the fast oscillation, measured from the c-wave peak, were significantly larger in Kir4.1+/- mice than in Kir4.1+/+ littermates. In comparison, the amplitude of the light peak, the other main component generated by the retinal pigment epithelium in response to light, did not differ between Kir4.1+/- and Kir4.1+/+ mice. The amplitude of slow PIII, revealed by the nob genetic background, was reduced in Kir4.1+/- mice.
conclusionsThese results indicate that a cornea-negative potential, generated by Kir4.1, normally opposes a positive polarity conductance that is generated by the apical membrane of the retinal pigment epithelium to form the c-wave measured at the corneal surface.
Indexed as
Identifiers
15359216PMC2883771W2150216672What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.