ArticleThe Journal of physiology2004
NG2-positive cells in the mouse white and grey matter display distinct physiological properties.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
128 citing papers in PubMed, 246 citations in OpenAlex.
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- Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells.Scientific reports · 2024Article
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- Gliomas: a reflection of temporal gliogenic principles.Communications biology · 2024Review
- Astrocyte ensheathment of calyx-forming axons of the auditory brainstem precedes accelerated expression of myelin genes and myelination by oligodendrocytes.The Journal of comparative neurology · 2024Article
- Intrinsic organization of the corpus callosum.Frontiers in physiology · 2024Review
- Nerve-Glial antigen 2: unmasking the enigmatic cellular identity in the central nervous system.Frontiers in immunology · 2024Review
- Glial Populations in the Human Brain Following Ischemic Injury.Biomedicines · 2023Review
- Glial progenitor cells of the adult human white and grey matter are contextually distinct.Glia · 2023Article
- High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS.Cell reports methods · 2023Article
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- Activity-dependent oligodendrocyte calcium dynamics and their changes in Alzheimer's disease.Frontiers in cellular neuroscience · 2023Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cells that express the NG2 proteoglycan are the largest proliferative progenitor population in the postnatal central nervous system (CNS). Although this entire population has long been considered to be oligodendrocyte progenitors, numerous NG2(+) cells are present in the cerebral cortex, where relatively little myelination occurs, and also persist long after myelination is complete in the CNS. Several studies have alluded to the presence of distinct NG2(+) cell subtypes based on marker expression, but no experimentally derived hypotheses about the physiological role of these subtypes has been proposed. In the current study, whole-cell patch-clamp data from acutely isolated slices demonstrate that subcortical white matter and cortical NG2(+) cells display distinct membrane properties in addition to possessing differing K(+)- and Na(+)-channel expression profiles. A striking observation is that a subpopulation of cortical, but not white matter NG2(+) cells, elicit depolarization-induced spikes that are akin to immature action potentials. Our data demonstrate that a population of cortical NG2(+) cells display physiological properties that differ from their white matter counterparts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.