ArticleJournal of the Association for Research in Otolaryngology : JARO2004
Efferent actions in the chinchilla vestibular labyrinth.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Differential Activation of Canal and Otolith Afferents by Acoustic Tone Bursts in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Context-independent encoding of passive and active self-motion in vestibular afferent fibers during locomotion in primates.Nature communications · 2022Article
- The mammalian efferent vestibular system utilizes cholinergic mechanisms to excite primary vestibular afferents.Scientific reports · 2021Article
- Loss of α-9 Nicotinic Acetylcholine Receptor Subunit Predominantly Results in Impaired Postural Stability Rather Than Gaze Stability.Frontiers in cellular neuroscience · 2021Article
- Differences in the Structure and Function of the Vestibular Efferent System Among Vertebrates.Frontiers in neuroscience · 2021Review
- Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear.Frontiers in neuroscience · 2021Article
- The Long and Winding Road-Vestibular Efferent Anatomy in Mice.Frontiers in neural circuits · 2021Article
- Activation of GABAJournal of neurophysiology · 2020Article
- Efferent synaptic transmission at the vestibular type II hair cell synapse.Journal of neurophysiology · 2020Article
- A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications.Journal of neurophysiology · 2020Review
- Efferent Inputs Are Required for Normal Function of Vestibular Nerve Afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.Journal of neurophysiology · 2018Article
- Influence of Magnitude and Duration of Altered Gravity and Readaptation to 1 g on the Structure and Function of the Utricle in Toadfish,Frontiers in physiology · 2018Article
- The Dynamics of Prosthetically Elicited Vestibulo-Ocular Reflex Function Across Frequency and Context in the Rhesus Monkey.Frontiers in neuroscience · 2018Article
- Muscarinic Acetylcholine Receptors and M-Currents Underlie Efferent-Mediated Slow Excitation in Calyx-Bearing Vestibular Afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Reviewing the Role of the Efferent Vestibular System in Motor and Vestibular Circuits.Frontiers in physiology · 2017Review
- Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista.Frontiers in cellular neuroscience · 2017Article
- The mammalian efferent vestibular system plays a crucial role in the high-frequency response and short-term adaptation of the vestibuloocular reflex.Journal of neurophysiology · 2015Article
- Neural response in vestibular organ of Helix aspersa to centrifugation and re-adaptation to normal gravity.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
- Efferent innervation of turtle semicircular canal cristae: comparisons with bird and mouse.The Journal of comparative neurology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Efferent fibers were electrically stimulated in the brain stem, while afferent activity was recorded from the superior vestibular nerve in barbiturate-anesthetized chinchillas. We concentrated on canal afferents, but otolith afferents were also studied. Among canal fibers, calyx afferents were recognized by their irregular discharge and low rotational gains. In separate experiments, stimulating electrodes were placed in the efferent cell groups ipsilateral or contralateral to the recording electrode or in the midline. While single shocks were ineffective, repetitive shock trains invariably led to increases in afferent discharge rate. Such excitatory responses consisted of fast and slow components. Fast components were large only at high shock frequencies (200-333/s), built up with exponential time constants <0.1 s, and showed response declines or adaptation during shock trains >1 s in duration. Slow responses were obtained even at shock rates of 50/s, built up and decayed with time constants of 15-30 s, and could show little adaptation. The more regular the discharge, the larger was the efferent response of an afferent fiber. Response magnitude was proportional to cv*b, a normalized coefficient of interspike-interval variation (cv*) raised to the power b = 0.7. The value of the exponent b did not depend on unit type (calyx vs. bouton plus dimorphic, canal vs. otolith) or on stimulation site (ipsilateral, contralateral, or midline). Responses were slightly smaller with contralateral or midline stimulation than with ipsilateral stimulation, and they were smaller for otolith, as compared to canal, fibers. An anatomical study had suggested that responses to contralateral afferent stimulation should be small or nonexistent in irregular canal fibers. The suggestion was not confirmed in this study. Contralateral responses, including the large responses typically seen in irregular fibers, were abolished by shallow midline incisions that should have severed crossing efferent axons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.