ArticleGenes and immunity2004
Cis-acting effect of the IL1B C-31T polymorphism on IL-1 beta mRNA expression.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia.Journal of molecular neuroscience : MN · 2014Trial
- Prognostic significance of inflammatory cytokine polymorphisms in AML: a study of IFNG, TNFA, and IL1B polymorphisms.BMC immunology · 2026Article
- Impact of inflammatory cytokine polymorphisms on the progression of myelodysplastic syndromes.Annals of hematology · 2025Article
- First insights into the molecular basis association between promoter polymorphisms of the IL1B gene and Helicobacter pylori infection in the Sudanese population: computational approach.BMC microbiology · 2021Article
- Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients.Medicina (Kaunas, Lithuania) · 2019Article
- Mouse models for gastric cancer: Matching models to biological questions.Journal of gastroenterology and hepatology · 2016Review
- Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study.BMC pregnancy and childbirth · 2016Article
- The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy.Journal of inflammation research · 2016Article
- Gene Variant and Level of IL-1β in Ischemic Stroke Patients With and Without Type 2 Diabetes Mellitus.Journal of molecular neuroscience : MN · 2015Article
- Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2015Article
- Genetic variants in genes of the inflammatory response in association with infective endocarditis.PloS one · 2014Article
- Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- Interleukin-1beta promoter (-31T/C and -511C/T) polymorphisms in major recurrent depression.Journal of molecular neuroscience : MN · 2011Article
- Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.World journal of gastroenterology · 2011Review
- Association between Interleukin-1B C-31T polymorphism and obesity in Japanese.Journal of epidemiology · 2009Article
- Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation.Cerebrovascular diseases (Basel, Switzerland) · 2009Article
- Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production.The Journal of infectious diseases · 2008Article
- A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population.Journal of human genetics · 2006Article
- The IL-1 gene family and bone involvement in celiac disease.Immunogenetics · 2005Article
- A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand.Malaria journal · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the effect of IL1B polymorphisms on IL-1beta production is still controversial, we selected two polymorphisms to test their cis-acting effect on IL-1beta mRNA expression by means of the allele-specific transcript quantification and the haplotype analysis. As for the C-31T polymorphism, we found that expression of the -31T allele was 2.2 times of the -31C allele. This higher transcription efficiency may correspond to the fact that C-31T is located in a TATA box. The other polymorphism, C+3954T, did not alter the levels of transcription. The use of the allele-specific transcript quantification enables us to exclude trans-acting effects of polymorphisms on the gene expression and contributes to understanding the roles of the IL1B polymorphisms in susceptibility to multifactorial diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.