ArticleMolecular biology of the cell2004
Arf1p provides an unexpected link between COPI vesicles and mRNA in Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Evolutionary trajectory for nuclear functions of ciliary transport complex proteins.Microbiology and molecular biology reviews : MMBR · 2024Review
- COPI coatomer subunit α-COP interacts with the RNA binding protein Nucleolin via a C-terminal dilysine motif.Human molecular genetics · 2023Article
- Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis.Nature cell biology · 2023Article
- Identification of RNA-Binding Protein Targets with HyperTRIBE inInternational journal of molecular sciences · 2023Article
- Hitchhiking Across Kingdoms: Cotransport of Cargos in Fungal, Animal, and Plant Cells.Annual review of cell and developmental biology · 2022Review
- The functional organization of axonal mRNA transport and translation.Nature reviews. Neuroscience · 2021Review
- SMN protein promotes membrane compartmentalization of ribosomal protein S6 transcript in human fibroblasts.Scientific reports · 2020Article
- Records of RNA locations in living yeast revealed through covalent marks.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Local Translation in Axons: When Membraneless RNP Granules Meet Membrane-Bound Organelles.Frontiers in molecular biosciences · 2019Review
- Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport.Trends in cell biology · 2017Review
- Protein-RNA networks revealed through covalent RNA marks.Nature methods · 2015Article
- The small GTPase Arf1 modulates mitochondrial morphology and function.The EMBO journal · 2014Article
- In Candida albicans hyphae, Sec2p is physically associated with SEC2 mRNA on secretory vesicles.Molecular microbiology · 2014Article
- COPI transport complexes bind to specific RNAs in neuronal cells.Human molecular genetics · 2013Article
- Conservation of the RNA Transport Machineries and Their Coupling to Translation Control across Eukaryotes.Comparative and functional genomics · 2012Article
- Cotranslational transport of ABP140 mRNA to the distal pole of S. cerevisiae.The EMBO journal · 2011Article
- The COPI vesicle complex binds and moves with survival motor neuron within axons.Human molecular genetics · 2011Article
- A novel mRNA affinity purification technique for the identification of interacting proteins and transcripts in ribonucleoprotein complexes.RNA (New York, N.Y.) · 2010Article
- Defects in the secretory pathway and high Ca2+ induce multiple P-bodies.Molecular biology of the cell · 2010Article
- A novel class of mRNA-containing cytoplasmic granules are produced in response to UV-irradiation.Molecular biology of the cell · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The small GTPase Arf1p is involved in different cellular processes that require its accumulation at specific cellular locations. The recruitment of Arf1p to distinct points of action might be achieved by association of Arf1p with different proteins. To identify new interactors of Arf1p, we performed an affinity chromatography with GTP- or GDP-bound Arf1p proteins. A new interactor of Arf1p-GTP was identified as Pab1p, which binds to the polyA-tail of mRNAs. Pab1p was found to associate with purified COPI-coated vesicles generated from Golgi membranes in vitro. The stability of the Pab1p-Arf1p complex depends on the presence of mRNA. Both symmetrically distributed mRNAs as well as the asymmetrically localized ASH1 mRNA are found in association with Arf1p. Remarkably, Arf1p and Pab1p are both required to restrict ASH1 mRNA to the bud tip. Arf1p and coatomer play an unexpected role in localizing mRNA independent and downstream of the SHE machinery. Hereby acts the SHE machinery in long-range mRNA transport, whereas COPI vesicles could act as short-range and localization vehicles. The endoplasmic reticulum (ER)-Golgi shuttle might be involved in concentrating mRNA at the ER.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.