ArticleMolecular biology of the cell2004
The small subunit processome is required for cell cycle progression at G1.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 75 citations in OpenAlex.
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- A role for the kinetochore protein, NUF2, in ribosome biogenesis.Molecular biology of the cell · 2025Article
- Annotation and functional prediction of RNA helicases inIMA fungus · 2025Review
- Mild heat treatment in vitro potentiates human adipose stem cells: delayed aging and improved quality for long term culture.Biomaterials research · 2023Article
- Large scale microfluidic CRISPR screening for increased amylase secretion in yeast.Lab on a chip · 2023Article
- The homeostatic regulation of ribosome biogenesis.Seminars in cell & developmental biology · 2023Review
- Article
- RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis.Cell death and differentiation · 2022Article
- Turnover of aberrant pre-40S pre-ribosomal particles is initiated by a novel endonucleolytic decay pathway.Nucleic acids research · 2018Article
- Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress.The Journal of cell biology · 2017Article
- Modeling osteosarcoma progression by measuring the connectivity dynamics using an inference of multiple differential modules algorithm.Molecular medicine reports · 2017Article
- New role of human ribosomal protein S3: Regulation of cell cycle via phosphorylation by cyclin-dependent kinase 2.Oncology letters · 2017Article
- Analysis of cell cycle parameters during the transition from unhindered growth to ribosomal and translational stress conditions.PloS one · 2017Article
- The Contributions of the Ribosome Biogenesis Protein Utp5/WDR43 to Craniofacial Development.Journal of dental research · 2016Review
- Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation.Nature communications · 2015Article
- Translate to divide: сontrol of the cell cycle by protein synthesis.Microbial cell (Graz, Austria) · 2015Review
- Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disorders.Biochimica et biophysica acta · 2014Review
- Repressed synthesis of ribosomal proteins generates protein-specific cell cycle and morphological phenotypes.Molecular biology of the cell · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Without ribosome biogenesis, translation of mRNA into protein ceases and cellular growth stops. We asked whether ribosome biogenesis is cell cycle regulated in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, and we determined that it is not regulated in the same manner as in metazoan cells. We therefore turned our attention to cellular sensors that relay cell size information via ribosome biogenesis. Our results indicate that the small subunit (SSU) processome, a complex consisting of 40 proteins and the U3 small nucleolar RNA necessary for ribosome biogenesis, is not mitotically regulated. Furthermore, Nan1/Utp17, an SSU processome protein, does not provide a link between ribosome biogenesis and cell growth. However, when individual SSU processome proteins are depleted, cells arrest in the G1 phase of the cell cycle. This arrest was further supported by the lack of staining for proteins expressed in post-G1. Similarly, synchronized cells depleted of SSU processome proteins did not enter G2. This suggests that when ribosomes are no longer made, the cells stall in the G1. Therefore, yeast cells must grow to a critical size, which is dependent upon having a sufficient number of ribosomes during the G1 phase of the cell cycle, before cell division can occur.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.