ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Hypothermia-associated loss of dendritic spines.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Hibernation-Inspired Innovations in Biomedicine: Addressing Aging, Chronic Diseases, and Critical Care.Canadian journal of zoology · 2026Article
- Transport and localization on dendrite-inspired flat band linear photonic lattices.Scientific reports · 2023Article
- Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Temperature-dependent structural plasticity of hippocampal synapses.Frontiers in cellular neuroscience · 2022Article
- Regrowth and neuronal protection are key for mammalian hibernation: roles for metabolic suppression.Neural regeneration research · 2020Review
- Dynamic balance of excitation and inhibition rapidly modulates spike probability and precision in feed-forward hippocampal circuits.Journal of neurophysiology · 2016Article
- Tracking the activity-dependent diffusion of synaptic proteins using restricted photoconversion of Dendra2.Frontiers in cellular neuroscience · 2015Article
- The role of cAMP in synaptic homeostasis in response to environmental temperature challenges and hyperexcitability mutations.Frontiers in cellular neuroscience · 2015Article
- Sleep and synaptic plasticity in the developing and adult brain.Current topics in behavioral neurosciences · 2015Review
- Beyond counts and shapes: studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy.Neuroscience · 2013Review
- Cytoskeletal regulation dominates temperature-sensitive proteomic changes of hibernation in forebrain of 13-lined ground squirrels.PloS one · 2013Article
- Nanoscale analysis of structural synaptic plasticity.Current opinion in neurobiology · 2012Review
- Neuroprotection: lessons from hibernators.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2012Review
- Molecular and cellular pathways as a target of therapeutic hypothermia: pharmacological aspect.Current neuropharmacology · 2012Article
- Erasing synapses in sleep: is it time to be SHY?Neural plasticity · 2012Review
- Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brain.Brain pathology (Zurich, Switzerland) · 2008Article
- Labeling of dendritic spines with the carbocyanine dye DiI for confocal microscopic imaging in lightly fixed cortical slices.Journal of neuroscience methods · 2007Article
- Motor impairment and neuronal damage following hypothermia in tropical amphibians.International journal of experimental pathology · 2007Article
- Ubiquitous and temperature-dependent neural plasticity in hibernators.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanisms of synaptic plasticity in CNS circuits are commonly investigated using in vitro preparations such as brain slices or slice culture. During their preparation, slices are exposed to low temperatures, and electrophysiological measurements are sometimes made below physiological temperature. Because dendritic spines, which occur at the majority of excitatory synapses, are morphologically plastic, we investigated the influence of reduced temperature on their morphology and plasticity using live cell imaging of hippocampal slices from transgenic mice expressing a green fluorescent protein-based neuronal surface marker and electron microscopy of adult brain slices. Our data show that dendritic spines are highly sensitive to reduced temperature with rapid loss of actin-based motility followed at longer times by reversible loss of the entire spine structure. Thus, reduced temperature significantly affects synaptic morphology, which is in turn known to influence several key aspects of synaptic transmission. Evidence that hypothermia potentiates anesthesia and is associated with spine loss in hibernating animals further suggests that spine morphology may have a widespread influence on brain function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.