ArticleThe Biochemical journal2005
The predominant polyphenol in the leaves of the resurrection plant Myrothamnus flabellifolius, 3,4,5 tri-O-galloylquinic acid, protects membranes against desiccation and free radical-induced oxidation.
Article in The Biochemical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 120 citations in OpenAlex.
- The architecture of resilience: a genome assembly of Myrothamnus flabellifolia sheds light on desiccation tolerance and sex determination.The New phytologist · 2026Article
- Anti-biofilm, anti-quorum sensing potential, cytotoxicity, and UPLC-UV/DAD-MS/MS/QTOF profiling of Prosopis Africana (Guill. & Perr.) Taub. leaves and stems extracts: benefits of a traditional medicine in dental care.BMC complementary medicine and therapies · 2025Article
- The promise of resurrection plants in enhancing crop tolerance to water scarcity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Life on the dry side: a roadmap to understanding desiccation tolerance and accelerating translational applications.Nature communications · 2025Review
- Relationship between secondary metabolites and ecological suitability zones for Eucommia ulmoides.PloS one · 2025Article
- Acclimation of the Resurrection PlantPlants (Basel, Switzerland) · 2024Article
- Evaluation of the Antioxidant, Cytotoxicity, Antibacterial, Anti-Motility, and Anti-Biofilm Effects ofPlants (Basel, Switzerland) · 2024Article
- Resurrection Plants-A Valuable Source of Natural Bioactive Compounds: From Word-of-Mouth to Scientifically Proven Sustainable Use.Metabolites · 2024Review
- Exploring the Potential ofAnimals : an open access journal from MDPI · 2022Review
- Integrative analysis of the pharmaceutical active ingredient and transcriptome of the aerial parts of Glycyrrhiza uralensis under salt stress reveals liquiritin accumulation via ABA-mediated signaling.Molecular genetics and genomics : MGG · 2022Article
- Two Decades of Desiccation Biology: A Systematic Review of the Best Studied Angiosperm Resurrection Plants.Plants (Basel, Switzerland) · 2021Review
- Systems biology of resurrection plants.Cellular and molecular life sciences : CMLS · 2021Review
- Genome-Wide Analysis of Serine Carboxypeptidase-Like Acyltransferase Gene Family for Evolution and Characterization of Enzymes Involved in the Biosynthesis of Galloylated Catechins in the Tea Plant (Frontiers in plant science · 2020Article
- Proteome Comparison Between Natural Desiccation-Tolerant Plants and Drought-ProtectedFrontiers in microbiology · 2020Article
- Metabolomic Profiling of the Desiccation-Tolerant Medicinal ShrubMolecules (Basel, Switzerland) · 2019Article
- NtMYB4 and NtCHS1 Are Critical Factors in the Regulation of Flavonoid Biosynthesis and Are Involved in Salinity Responsiveness.Frontiers in plant science · 2019Article
- Dietary Flavonoids in the Prevention of T2D: An Overview.Nutrients · 2018Review
- Perspectives on Structural, Physiological, Cellular, and Molecular Responses to Desiccation in Resurrection Plants.Scientifica · 2018Review
- Photoprotection conferred by changes in photosynthetic protein levels and organization during dehydration of a homoiochlorophyllous resurrection plant.Plant physiology · 2015Article
- In vivo spectroscopy and NMR metabolite fingerprinting approaches to connect the dynamics of photosynthetic and metabolic phenotypes in resurrection plant Haberlea rhodopensis during desiccation and recovery.Frontiers in plant science · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The predominant (>90%) low-molecular-mass polyphenol was isolated from the leaves of the resurrection plant Myrothamnus flabellifolius and identified to be 3,4,5 tri-O-galloylquinic acid using 1H and 13C one- and two-dimensional NMR spectroscopy. The structure was confirmed by mass spectrometric analysis. This compound was present at high concentrations, 44% (by weight) in hydrated leaves and 74% (by weight) in dehydrated leaves. Electron microscopy of leaf material fixed with glutaraldehyde and caffeine demonstrated that the polyphenols were localized in large vacuoles in both hydrated and dehydrated leaves. 3,4,5 Tri-O-galloylquinic acid was shown to stabilize an artificial membrane system, liposomes, against desiccation if the polyphenol concentration was between 1 and 2 microg/mug phospholipid. The phase transition of these liposomes observed at 46 degrees C was markedly diminished by the presence of 3,4,5 tri-O-galloylquinic acid, suggesting that the presence of the polyphenol maintained the membranes in the liquid crystalline phase at physiological temperatures. 3,4,5 Tri-O-galloylquinic acid was also shown to protect linoleic acid against free radical-induced oxidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.