ArticleThe Journal of cell biology2004
A novel checkpoint in the Bcl-2-regulated apoptotic pathway revealed by murine cytomegalovirus infection of dendritic cells.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus.Scientific reports · 2016Article
- BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells.Journal of virology · 2015Article
- Identification of cellular proteins that interact with human cytomegalovirus immediate-early protein 1 by protein array assay.Viruses · 2013Article
- MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication.PLoS pathogens · 2013Article
- Prevention of cellular suicide by cytomegaloviruses.Viruses · 2012Review
- Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function.Immunology and cell biology · 2011Article
- Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins.Journal of virology · 2008Article
- Murine cytomegalovirus m38.5 protein inhibits Bax-mediated cell death.Journal of virology · 2008Article
- Induction of apoptosis limits cytomegalovirus cross-species infection.The EMBO journal · 2006Article
- Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection.Journal of virology · 2006Article
- Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria.Journal of virology · 2006Article
- Mitochondrial cell death suppressors carried by human and murine cytomegalovirus confer resistance to proteasome inhibitor-induced apoptosis.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Infection with murine cytomegalovirus (MCMV) has contributed to understanding many aspects of human infection and, additionally, has provided important insight to understanding complex cellular responses. Dendritic cells (DCs) are a major target for MCMV infection. Here, we analyze the effects of MCMV infection on DC viability, and show that infected DCs become resistant to apoptosis induced by growth factor deprivation. The precise contribution of changes in the expression of Bcl-2 family proteins has been assessed and a new checkpoint in the apoptotic pathway identified. Despite their resistance to apoptosis, MCMV-infected DCs showed Bax to be tightly associated with mitochondria and, together with Bak, forming high molecular weight oligomers, changes normally associated with apoptotic cell death. Exposure of a constitutively occluded Bax NH2-terminal epitope was blocked after infection. These results suggest that MCMV has evolved a novel strategy for inhibiting apoptosis and provide evidence that apoptosis can be regulated after translocation, integration, and oligomerization of Bax at the mitochondrial membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.