Evidence map›Paper›PMID 15350737›Full record

ArticleJournal of virological methods2004

Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV.

Miriam E R Darnell, Kanta Subbarao, Stephen M Feinstone, Deborah R Taylor

Abstract read
In one paragraph

Article in Journal of virological methods, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 338 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
338citing papers in PubMed, 6 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

338 citing papers in PubMed, 6 syntheses or guidelines pooled it, 750 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Proton Pump Inhibitor Use Is Not Strongly Associated With SARS-CoV-2 Related Outcomes: A Nationwide Study and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021
    Pooled it
  5. Pooled it
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  7. Article
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  11. A Virus Aerosol Chamber Study: The Impact of UVA, UVC, and HEnvironment & health (Washington, D.C.) · 2025
    Article
  12. Review
  13. Review
  14. Article
  15. Evaluation of the killing effects of UVFrontiers in veterinary science · 2025
    Article
  16. Article
  17. Approaches for the Inactivation ofApplied biosafety : journal of the American Biological Safety Association · 2024
    Article
  18. Article
  19. Article
  20. Article

278 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Miriam E R DarnellCenter for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, HFM448, Bethesda, MD 20892, USA.
Kanta Subbarao
Stephen M Feinstone
Deborah R Taylor
United States Food and Drug Administration · USCenter for Biologics Evaluation and Research · USNational Institute of Allergy and Infectious Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a novel coronavirus termed SARS-CoV. Due to the severity of this disease, the World Health Organization (WHO) recommends that manipulation of active viral cultures of SARS-CoV be performed in containment laboratories at biosafety level 3 (BSL3). The virus was inactivated by ultraviolet light (UV) at 254 nm, heat treatment of 65 degrees C or greater, alkaline (pH > 12) or acidic (pH < 3) conditions, formalin and glutaraldehyde treatments. We describe the kinetics of these efficient viral inactivation methods, which will allow research with SARS-CoV containing materials, that are rendered non-infectious, to be conducted at reduced safety levels.

Indexed as

Virus InactivationAnimalsAntiviral AgentsChlorocebus aethiopsFormaldehydeGlutaralHot TemperatureHydrogen-Ion ConcentrationKineticsSevere acute respiratory syndrome-related coronavirusTime FactorsUltraviolet RaysVero CellsAntiviral AgentsFormaldehydeGlutaral

Identifiers

PMID15350737
PMCPMC7112912
OpenAlexW2153300342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.