ArticleHuman genetics2004
Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineage.
Article in Human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Deploying the drug repurposing approach for the identification of selective monoamine oxidase-B inhibitors against neurological disabilities: an in Silico and in vitro approach.Journal of computer-aided molecular design · 2025Article
- The coevolution of cooperation and cognition in humans.Proceedings. Biological sciences · 2018Article
- Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents.Molecules (Basel, Switzerland) · 2017Article
- Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity.Molecules (Basel, Switzerland) · 2017Article
- Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review.Frontiers in psychology · 2016Review
- Genome-wide scans for footprints of natural selection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases.Biochemistry · 2009Review
- Genetic basis of human brain evolution.Trends in neurosciences · 2008Review
- Built-in loops allow versatility in domain-domain interactions: lessons from self-interacting domains.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Adaptive evolution of genes underlying schizophrenia.Proceedings. Biological sciences · 2007Article
- Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas.BMC genetics · 2007Article
- Gathering computational genomics and proteomics to unravel adaptive evolution.Evolutionary bioinformatics online · 2007Article
- Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B.Archives of biochemistry and biophysics · 2007Review
- Do monomeric vs dimeric forms of MAO-A make a difference? A direct comparison of the catalytic properties of rat and human MAO-A's.Journal of neural transmission (Vienna, Austria : 1996) · 2007Article
- New insights into the structures and functions of human monoamine oxidases A and B.Journal of neural transmission (Vienna, Austria : 1996) · 2007Article
- Ancient and recent positive selection transformed opioid cis-regulation in humans.PLoS biology · 2005Article
- Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Comparative modelling of protein structure and its impact on microbial cell factories.Microbial cell factories · 2005Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monoamine oxidase A (MAOA) is the X-linked gene responsible for deamination and subsequent degradation of several neurotransmitters and other amines. Among other activities, the gene has been shown to play a role in locomotion, circadian rhythm, and pain sensitivity and to have a critical influence on behavior and cognition. Previous studies have reported a non-neutral evolution of the gene attributable to positive selection in the human lineage. To determine whether this selection was human-exclusive or shared with other species, we performed a population genetic analysis of the pattern of nucleotide variation in non-human species, including bonobo, chimpanzee, gorilla, and orangutan. Footprints of positive selection were absent in all analyzed species, suggesting that positive selection has been recent and unique to humans. To determine which human-unique genetic changes could have been responsible for this differential evolution, the coding region of the gene was compared between human, chimpanzee, and gorilla. Only one human exclusive non-conservative change is present in the gene: Glu151Lys. This human substitution affects protein dimerization according to a three-dimensional structural model that predicts a non-negligible functional shift. This is the only candidate position at present to have been selected to fixation in humans during an episode of positive selection. Divergence analysis among species has shown that, even under positive selection in the human lineage, the MAOA gene did not experience accelerated evolution in any of the analyzed lineages, and that tools such as K(a)/ K(s) would not have detected the selective history of the gene.
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