ArticleJournal of materials science. Materials in medicine1997
Modulation of the phenotypic and functional properties of phagocytic macrophages by wear particles from orthopaedic implants.
Article in Journal of materials science. Materials in medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- Macrophage-associated biocompatibility of titanium revealed by analyzing foreign body reaction at bone-implant interface.The journal of advanced prosthodontics · 2025Article
- Fatigue Crack Growth and Fracture of Internal Fixation Materials in In Vivo Environments-A Review.Materials (Basel, Switzerland) · 2021Review
- Increased expression of inducible co-stimulator on CD4+ T-cells in the peripheral blood and synovial fluid of patients with failed hip arthroplasties.Bone & joint research · 2016Article
- Localized immunosuppressive environment in the foreign body response to implanted biomaterials.The American journal of pathology · 2009Article
- The combined role of wear particles, macrophages and lymphocytes in the loosening of total joint prostheses.Journal of the Royal Society, Interface · 2008Review
- Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections.BMC biotechnology · 2008Article
- Foreign body reaction to biomaterials.Seminars in immunology · 2008Review
- Quantification of the bone-related mRNAs at the bone/prosthetic interface.Journal of materials science. Materials in medicine · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An attempt was made to assess the local chronic inflammatory response in patients with failed orthopaedic implant that is clinically associated with osteolysis, bone and bone marrow necrosis. The main objective was to analyse the heterogeneity of the macrophage functional subsets in the bone-implant interface membrane and to evaluate their possible role in the development of an erosive inflammatory lesion within the bone. Immunohistology was performed on 21 specimens of the bone-implant interface obtained from 17 patients during revision arthroplasty, and synovial membranes from rheumatoid (RA, n=4), and osteoarthritis (OA, n=4) patients. Three well-characterized monoclonal antibodies (MAb) recognizing antigenic determinants on specific functional subsets of macrophages (Mphi) were used. RFD1 (interdigitating reticulum cells/antigen presenting cells, (APC), RFD7 (mature phagocytic macrophages), and RFD9 epithelioid cells and foreign body giant cells (FBGC). RFD1 was expressed on a variable number of perivascular and synovial lining Mphi in both RA and OA synovia, at a frequency of 25%-40%. In cases with total joint replacements, the interface showed a marked increase in the expression of RFD1 (20%-90%). A considerably greater percentage of RFD1 positive Mphi and FBGC was noted in the interfaces from cases with a high level of detectable metal particulate wear debris (mean 80%, range 60%-90%) than in cases with polyethylene wear debris (mean 30%, range 0%-50%), p 0.0001. RFD7 labelled most tissue Mphi in each group. Immunoreactivity for RFD9 was restricted to FBGC in all cases analysed. The finding of elevated expression of RFD1 on metal-containing Mphi and FBGC in the bone-implant interface suggests an increase in antigen-presenting phenotype and indicates that metal particles have more impact in the induction of immune-mediated responses. Such responses are characterized by sustained cellular hyperreactivity and phenotypic changes in Mphi subsets.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.