ArticleJournal of materials science. Materials in medicine2002
Human-osteoblast proliferation and differentiation on grit-blasted and bioactive titanium for dental applications.
Article in Journal of materials science. Materials in medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 84 citations in OpenAlex.
- A Radiographic and Clinical Comparison of Immediate vs. Early Loading (4 Weeks) of Implants with a New Thermo-Chemically Treated Surface: A Randomized Clinical Trial.International journal of environmental research and public health · 2021Trial
- Critical Questions Surrounding the Shot-Blasting Treatment of Titanium Dental Implants.Materials (Basel, Switzerland) · 2025Review
- Tailoring the surface pore morphology of bioceramic scaffolds through colloidal processing for bone tissue engineering.PloS one · 2025Article
- Influence of Titanium Surface Residual Stresses on Osteoblastic Response and Bacteria Colonization.Materials (Basel, Switzerland) · 2024Article
- Relevant Aspects of Titanium Topography for Osteoblastic Adhesion and Inhibition of Bacterial Colonization.Materials (Basel, Switzerland) · 2023Article
- Bacteriostatic Poly Ethylene Glycol Plasma Coatings for Orthodontic Titanium Mini-Implants.Materials (Basel, Switzerland) · 2022Article
- Investigations on the Influence of Collagen Type on Physicochemical Properties of PVP/PVA Composites Enriched with Hydroxyapatite Developed for Biomedical Applications.Materials (Basel, Switzerland) · 2021Article
- Mineralization of Titanium Surfaces: Biomimetic Implants.Materials (Basel, Switzerland) · 2021Review
- Effects of UV Treatment on Ceria-Stabilized Zirconia/Alumina Nanocomposite (NANOZR).Materials (Basel, Switzerland) · 2020Article
- Assessment of Dental Implants with Modified Calcium-Phosphate Surface in a Multicenter, Prospective, Non-Interventional Study: Results up to 50 Months of Follow-Up.Journal of functional biomaterials · 2019Article
- Hybrid nanotopographical surfaces obtained by biomimetic mineralization of statherin-inspired elastin-like recombinamers.Advanced healthcare materials · 2014Article
- Biomimetic treatment on dental implants for short-term bone regeneration.Clinical oral investigations · 2014Article
- Adult stem cells properties in terms of commitment, aging and biological safety of grit-blasted and Acid-etched ti dental implants surfaces.International journal of molecular and cellular medicine · 2014Article
- Influence of acid-etching after grit-blasted on osseointegration of titanium dental implants: in vitro and in vivo studies.Journal of materials science. Materials in medicine · 2013Article
- Effect of blasting treatment and Fn coating on MG63 adhesion and differentiation on titanium: a gene expression study using real-time RT-PCR.Journal of materials science. Materials in medicine · 2011Article
- Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives.Nanoscale · 2011Review
- Formation of calcium phosphates on titanium implants with four different bioactive surface preparations. An in vitro study.Journal of materials science. Materials in medicine · 2007Article
- Enhanced wear and fatigue properties of Ti-6Al-4V alloy modified by plasma carburizing/CrN coating.Journal of materials science. Materials in medicine · 2007Article
- An electrodeposition method of calcium phosphate coatings on titanium alloy.Journal of materials science. Materials in medicine · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physico-chemical and topographical surface quality of commercially pure titanium (c.p. Ti) dental implants is one of the most influencing factors in the improvement of their osseointegration. In this sense, previously, a two-step method (2S) for obtaining bioactive blasted-rough titanium surfaces was developed for improving short-term (due to its bioactivity) and long-term (due to its roughness) osseointegration. This 2S-method consists of: (1) Grit blasting on titanium surface in order to roughen it, and (2) thermo-chemical (TCh) treatment in order to obtain a bioactive surface with bone-bonding ability. The aim of the present work is to evaluate the in vitro human-osteoblast response (proliferation, differentiation - ALP activity- and cell morphology-studied by environmental scanning electron microscopy) of rough c.p. Ti (grit blasted), bioactive c.p. Ti (thermo-chemically treated) and rough-bioactive c.p. Ti (2S-treated). Different grit materials (Al(2)O(3) and SiC) have been used in order to investigate their influence. The results showed that cell adhesion was statistically higher for the rough and bioactive surfaces, whatever the grit used. Cells proliferated very well on all the c.p. Ti surfaces. If comparing groups with and without TCh (all other treatments being equal) the ALP was always higher in the groups with TCh, indicating stimulation of osteoblast differentiation because of TCh, more significantly in the groups that were first blasted. Those ALP results were accompanied by a decrease in the value of proliferation, which shows the good behavior of the cells. This results suggest that a rough and bioactive-titanium surface obtained by 2S-treatment enhances adhesion and differentiation activity of human osteoblasts cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.