ArticleJournal of materials science. Materials in medicine2001
Macroporous biphasic calcium phosphate ceramics versus injectable bone substitute: a comparative study 3 and 8 weeks after implantation in rabbit bone.
Article in Journal of materials science. Materials in medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 91 citations in OpenAlex.
- Hemostatic efficacy of a novel Ca/P/S-based bone graft material and its preliminary clinical evidence in sternum closure procedures.Frontiers in bioengineering and biotechnology · 2026Article
- Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration.Bioactive materials · 2023Article
- Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review.Materials (Basel, Switzerland) · 2022Review
- Physical/Chemical Properties and Resorption Behavior of a Newly Developed Ca/P/S-Based Bone Substitute Material.Materials (Basel, Switzerland) · 2020Article
- Evaluation of Peri-Implant Bone Grafting Around Surface-Porous Dental Implants: An In Vivo Study in a Goat Model.Materials (Basel, Switzerland) · 2019Article
- Bioactive glass in tissue engineering.Acta biomaterialia · 2011Review
- Initial biocompatibility and enhanced osteoblast response of Si doping in a porous BCP bone graft substitute.Journal of materials science. Materials in medicine · 2010Article
- Injectable biomaterials for regenerating complex craniofacial tissues.Advanced materials (Deerfield Beach, Fla.) · 2009Article
- In vivo behaviour of two different biphasic ceramic implanted in mandibular bone of dogs.Journal of materials science. Materials in medicine · 2008Article
- In vivo evaluation of an injectable Macroporous Calcium Phosphate Cement.Journal of materials science. Materials in medicine · 2007Article
- Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macroporous biphasic calcium phosphate ceramics (MBCP) and a calcium phosphate injectable bone substitute (IBS), obtained by the association of biphasic calcium phosphate (BCP) ceramic granules and an aqueous solution of a cellulosic polymer, were compared in the same animal model. The two tested biomaterials were implanted in distal femoral osseous defects in rabbits. Qualitative and quantitative histological evaluation was performed three and eight weeks after implantation to investigate bone colonization and ceramic biodegradation associated with the two bone substitutes. Both biomaterials expressed osteoconduction properties and supported the apposition of a well-mineralized lamellar newly-formed bone. Bone colonization occurred much earlier and faster for IBS than for MBCP implants, although the respective rates of newly-formed bone after eight weeks of implantation did not differ significantly. For both biomaterials, ceramic resorption occurred regularly throughout the implantation period, though to a greater extent with IBS than with MBCP implants. The associated polymer in IBS produced intergranular spaces allowing body fluids to reach each BCP ceramic granule immediately after implantation, which may have favored osteoblastic activity, new bone formation and ceramic resorption. This completely interconnected open macroporosity could account for the earlier and more satisfactory bone substitution achieved with IBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.