ArticleJournal of materials science. Materials in medicine2001
Hydroxyapatite particles are capable of inducing osteoclast formation.
Article in Journal of materials science. Materials in medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Advanced applications of strontium-containing biomaterials in bone tissue engineering.Materials today. Bio · 2023Review
- Monocyte Differentiation on Atomic Layer-Deposited (ALD) Hydroxyapatite Coating on Titanium Substrate.Molecules (Basel, Switzerland) · 2023Article
- Aspirin synergizes with mineral particle-coated macroporous scaffolds for bone regeneration through immunomodulation.Theranostics · 2023Article
- Osteoblast Attachment on Titanium Coated with Hydroxyapatite by Atomic Layer Deposition.Biomolecules · 2022Article
- Feedback-Controlled Release of Alendronate from Composite Microparticles.Journal of functional biomaterials · 2020Article
- Calcium ions and osteoclastogenesis initiate the induction of bone formation by coral-derived macroporous constructs.Journal of cellular and molecular medicine · 2013Article
- Postoperative lumbar spinal stenosis after intertransverse fusion with granules of hydroxyapatite: a case report.Diagnostic pathology · 2012Article
- Spherical N-carboxyethylchitosan/hydroxyapatite nanoparticles prepared by ionic diffusion process in a controlled manner.Journal of materials science. Materials in medicine · 2010Article
- The influence of surface mineral and osteopontin on the formation and function of murine bone marrow-derived osteoclasts.Journal of materials science. Materials in medicine · 2008Article
- A comparison of different nanostructured biomaterials in subcutaneous tissue.Journal of materials science. Materials in medicine · 2008Article
- The properties of biomimetically processed calcium phosphate on bioactive ceramics and their response on bone cells.Journal of materials science. Materials in medicine · 2006Article
- Morphological features of osteoclasts derived from a co-culture system.Journal of molecular histology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydroxyapatite (HA) coatings have been used to improve implant fixation by promoting bone formation around the prosthesis. A macrophage response to HA particulates has been noted around loosened HA-coated prostheses. As biomaterial wear particle-associated macrophages are known to be capable of differentiating into osteoclasts that are capable of bone resorption, we examined whether particulate HA could similarly induce macrophage-osteoclast differentiation. HA-associated macrophages were isolated from granulomas, formed by subcutaneous implantation of HA, and co-cultured with UMR 106 osteoblast-like cells in the presence of 1,25-dihydroxyvitamin D(3) for up to 14 days on glass coverslips and bone slices. HA-associated macrophage-osteoclast differentiation was evidenced by the formation of numerous multinucleated tartrate resistant acid phosphatase (TRAP)-positive cells which formed lacunar resorption pits on bone slices. Polymethylmethacrylate (PMMA) particle-associated macrophages, isolated from subcutaneous PMMA-containing granulomas, caused significantly more osteoclast formation and bone resorption than HA-associated macrophages. These results indicate that macrophages responding to HA particles are capable of osteoclast differentiation. They also suggest that particles derived from uncemented (HA-coated) implants are likely to induce less osteoclast formation and osteolysis than cemented implants.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.