ReviewClinical reviews in allergy & immunology2004
Airway remodeling: lessons from animal models.
Review in Clinical reviews in allergy & immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 45 citations in OpenAlex.
- Guishaozichuan granules can attenuate asthma in ratsFrontiers in pharmacology · 2022Article
- Airway Hyperresponsiveness, Inflammation, and Pulmonary Emphysema in Rodent Models Designed to Mimic Exposure to Fuel Oil-Derived Volatile Organic Compounds Encountered during an Experimental Oil Spill.Environmental health perspectives · 2020Article
- Lung morphometry changes in prevention of airway remodeling by protocatechuic aldehyde in asthmatic mice.International journal of clinical and experimental medicine · 2015Article
- Significance of persistent inflammation in respiratory disorders induced by nanoparticles.Journal of immunology research · 2014Review
- Maternal allergen exposure reprograms the developmental lung transcriptome in atopic and normoresponsive rat pups.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control.Proceedings of the American Thoracic Society · 2009Review
- Inorganic arsenic as a developmental toxicant: in utero exposure and alterations in the developing rat lungs.Molecular nutrition & food research · 2009Article
- c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis.American journal of respiratory cell and molecular biology · 2009Article
- Three paradigms of airway smooth muscle hyperresponsiveness in young guinea pigs.Canadian journal of physiology and pharmacology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airway remodeling, an array of persistent tissue structural changes that occurs through a process of injury and dysregulated repair linked to airway chronic inflammation, is presently believed to largely account for the disease mechanisms of asthma. Increases in airway smooth muscle mass are probably the main mechanism causing airway hyperresponsiveness, and changes in the extracellular matrix may stimulate smooth muscle growth and contribute to the mechanics of airway obstruction. The various components of airway remodeling described inhuman asthma have been successfully reproduced in animal models of several species. Most of the data have been contributed by rat models of allergic sensitization and repeated challenge,transgenic mouse models of cytokine overexpression localized to the lung and, more recently, allergen-driven mouse models using wild-type inbred strains. Overall, animal model shave provided significant insights into the mechanisms of airway remodeling and recent technological developments allow us to exploit these models in new directions. However, the challenge of finding new therapeutic strategies that prevent or control airway remodeling,thus providing etiopathogenically oriented treatments for asthma, still stands. Experimental airway remodeling in animals should be an essential tool for treatment discovery in the near future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.