Evidence map›Paper›PMID 15347260›Full record

ReviewExpert review of molecular diagnostics2004

Advanced molecular cytogenetics in human and mouse.

Kathleen Dorritie, Cristina Montagna, Michael J Difilippantonio, Thomas Ried

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Expert review of molecular diagnostics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Chromosome instability and aneuploidy in the mammalian brain.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Defining a genotoxic profile with mouse embryonic stem cells.Experimental biology and medicine (Maywood, N.J.) · 2013
    Review
  9. DNA methylation changes in murine breast adenocarcinomas allow the identification of candidate genes for human breast carcinogenesis.Mammalian genome : official journal of the International Mammalian Genome Society · 2011
    Article
  10. Genetic diagnostic methods for inherited eye diseases.Middle East African journal of ophthalmology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kathleen DorritieNew York State Medical School, USA. dorritik@upstate.edu
Cristina Montagna
Michael J Difilippantonio
Thomas Ried
Center for Cancer Research · USSUNY Upstate Medical University · US

Funding

Patterns and mechanisms of chromosomal aberrationsZ01SC010298 · SC · CLINICAL SCIENCES · PI RIED, THOMAS E. · 1999 to 2006
–
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Fluorescence in situ hybridization, spectral karyotyping, multiplex fluorescence in situ hybridization, comparative genomic hybridization, and more recently array comparative genomic hybridization, represent advancements in the field of molecular cytogenetics. The application of these techniques for the analysis of specimens from humans, or mouse models of human diseases, enables one to reliably identify and characterize complex chromosomal rearrangements resulting in alterations of the genome. As each of these techniques has advantages and limitations, a comprehensive analysis of cytogenetic aberrations can be accomplished through the utilization of a combination approach. As such, analyses of specific tumor types have proven invaluable in the identification of new tumor-specific chromosomal aberrations and imbalances (aneuploidy), as well as regions containing tumor-specific gene targets. Application of these techniques has already improved the classification of tumors into distinct categories, with the hope that this will lead to more tailored treatment strategies. These techniques, in particular the application of tumor-specific fluorescence in situ hybridization probes to interphase nuclei, are also powerful tools for the early identification of premalignant lesions.

Indexed as

AnimalsChromosome AberrationsCytogeneticsHumansIn Situ Hybridization, FluorescenceMetaphaseMiceNeoplasmsNucleic Acid HybridizationSpectral Karyotyping

Identifiers

PMID15347260
PMCPMC4729310
OpenAlexW2092132944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.