ArticleBiophysical journal2004
Using atomic force microscopy to study nucleosome remodeling on individual nucleosomal arrays in situ.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Multiscale modeling primer: Focus on chromatin and epigenetics.The Journal of biological chemistry · 2026Review
- Atomic Force Microscopy Reveals that the Drosophila Telomere-Capping Protein Verrocchio Is a Single-Stranded DNA-Binding Protein.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Constructing arrays of nucleosome positioning sequences using Gibson Assembly for single-molecule studies.Scientific reports · 2020Article
- Atomic force microscopy of chromatin arrays reveal non-monotonic salt dependence of array compaction in solution.PloS one · 2017Article
- Nanopores suggest a negligible influence of CpG methylation on nucleosome packaging and stability.Nano letters · 2015Article
- Characterization of an antibody scFv that recognizes fibrillar insulin and beta-amyloid using atomic force microscopy.Nanomedicine : nanotechnology, biology, and medicine · 2008Article
- Using atomic force microscopy to study chromatin structure and nucleosome remodeling.Methods (San Diego, Calif.) · 2007Article
- Two-component atomic force microscopy recognition imaging of complex samples.Analytical biochemistry · 2007Article
- Localization of linker histone in chromatosomes by cryo-atomic force microscopy.Biophysical journal · 2006Article
- Organization of interphase chromatin.Chromosoma · 2006Review
- Solution AFM studies of human Swi-Snf and its interactions with MMTV DNA and chromatin.Biophysical journal · 2005Article
- Single-molecule recognition imaging microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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Authors and funding
6 authors.
Funding
Abstract
In eukaryotes, genomic processes like transcription, replication, repair, and recombination typically require alterations in nucleosome structure on specific DNA regions to operate. ATP-dependent nucleosome remodeling complexes provide a major mechanism for carrying out such alterations in vivo. To learn more about the action of these important complexes, we have utilized an atomic force microscopy in situ technique that permits comparison of the same individual molecules before and after activation of a particular process, in this case nucleosome remodeling. This direct approach was used to look for changes induced by the action of the human Swi-Snf remodeling complex on individual, single-copy mouse mammary tumor virus promoter nucleosomal arrays. Using this technique, we detect a variety of changes on remodeling. Many of these changes are larger in scale than suggested from previous studies and involve a number of DNA-mediated events, including a preference for the removal of a complete turn (80 basepairs) of nucleosomal DNA. The latter result raises the possibility of an unanticipated mode of human Swi-Snf interaction with the nucleosome, namely via the 11-nm histone surface.
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