Evidence map›Paper›PMID 15345550›Full record

ArticleBiophysical journal2004

Interaction of poly(L-lysine)-g-poly(ethylene glycol) with supported phospholipid bilayers.

Fernanda F Rossetti, Ilya Reviakine, Gábor Csúcs, Fabiano Assi, János Vörös, Marcus Textor

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Fernanda F RossettiBio Interface Group, Laboratory for Surface Science and Technology, Department of Materials, Swiss Federal Institute of Technology, Zurich, Switzerland.
Ilya Reviakine
Gábor Csúcs
Fabiano Assi
János Vörös
Marcus Textor
École Polytechnique Fédérale de Lausanne · CHUniversity of Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interactions between the graft copolymer poly(L-lysine)-g-poly(ethylene glycol), PLL-g-PEG, and two kinds of surface-supported lipidic systems (supported phospholipid bilayers and supported vesicular layers) were investigated by a combination of microscopic and spectroscopic techniques. It was found that the application of the copolymer to zwitterionic or negatively charged supported bilayers in a buffer of low ionic strength led to their decomposition, with the resulting formation of free copolymer-lipid complexes. The same copolymer had no destructive effect on a supported vesicular layer made up of vesicles of identical composition. A comparison between poly(L-lysine), which did not induce decomposition of supported bilayers, and PLL-g-PEG copolymers with various amounts of PEG side chains per backbone lysine unit, suggested that steric repulsion between the PEG chains that developed upon adsorption of the polymer to the nearly planar surface of a supported phospholipid bilayer (SPB) was one of the factors responsible for the destruction of the SPBs by the copolymer. Other factors included the ionic strength of the buffer used and the quality of the bilayers, pointing toward the important role defects present in the SPBs play in the decomposition process.

Indexed as

AdsorptionBiophysicsBuffersCalciumChloroformIonsLipid BilayersLipidsMicroscopy, FluorescenceModels, MolecularPhosphatidylcholinesPhosphatidylserinesPhospholipidsPolyethylene GlycolsPolylysinePolymers1,2-dioleoylphosphatidylserine1,2-oleoylphosphatidylcholineBuffersCalciumChloroformIonsLipid BilayersLipidsPhosphatidylcholinesPhosphatidylserinesPhospholipidsPolyethylene GlycolsPolylysinepolylysine-graft-(poly(ethylene glycol))Polymers

Identifiers

PMID15345550
PMCPMC1304576
OpenAlexW2047176776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.