ArticleBiophysical journal2004
Proton conductance of influenza virus M2 protein in planar lipid bilayers.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K with Well-Characterized Viroporins.Viruses · 2025Review
- Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses.Frontiers in immunology · 2022Review
- Review
- Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+.Science signaling · 2014Article
- Article
- Activation and proton transport mechanism in influenza A M2 channel.Biophysical journal · 2013Article
- The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.Chemical reviews · 2013Review
- Self-assembling subnanometer pores with unusual mass-transport properties.Nature communications · 2012Article
- Mechanism of function of viral channel proteins and implications for drug development.International review of cell and molecular biology · 2012Review
- A role for anions in ATP synthesis and its molecular mechanistic interpretation.Journal of bioenergetics and biomembranes · 2011Article
- A theory for the proton transport of the influenza virus M2 protein: extensive test against conductance data.Biophysical journal · 2011Article
- Functional reconstitution of influenza A M2(22-62).Biochimica et biophysica acta · 2011Article
- Multiple Proton Confinement in the M2 Channel from the Influenza A Virus.The journal of physical chemistry. C, Nanomaterials and interfaces · 2010Article
- Assembly of the m2 tetramer is strongly modulated by lipid chain length.Biophysical journal · 2010Article
- Proton and cation transport activity of the M2 proton channel from influenza A virus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Structure and dynamics of the influenza A M2 channel: a comparison of three structures.Journal of molecular modeling · 2009Article
- Article
- Structure and function of the influenza A M2 proton channel.Biochemistry · 2009Article
- Self-assembly of a simple membrane protein: coarse-grained molecular dynamics simulations of the influenza M2 channel.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Purified M2 protein from the Udorn strain of influenza virus was reconstituted into planar lipid bilayers from liposomes. In 1 mM HCl, the single-channel conductance was measured as 6 pS with open probability of < or =0.03. The current voltage curve is linear over the achievable voltage range. The current amplitude is amantadine sensitive. In HCl solutions, the single-channel current was essentially invariant with changes in [Cl(-)], [Na(+)], and [tetraethylammonium] ([TEA(+)]), but dependent on [H(+)]. The reversal potential, determined with asymmetrical hydrogen chloride solution, is very close to the equilibrium potential of hydrogen. This appears to be the first report of single-channel proton currents with the full-length M2 protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.