ArticleBiophysical journal2004
A signal transduction pathway model prototype I: From agonist to cellular endpoint.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
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- An integrated mathematical model of thrombin-, histamine-and VEGF-mediated signalling in endothelial permeability.BMC systems biology · 2011Article
- Modeling species-specific diacylglycerol dynamics in the RAW 264.7 macrophage.Journal of theoretical biology · 2010Article
- Use of virtual cell in studies of cellular dynamics.International review of cell and molecular biology · 2010Review
- Systemic Analysis of Tumor Cell-Induced Endothelial Calcium Signaling and Junction Disassembly.Cellular and molecular bioengineering · 2009Article
- CellML metadata standards, associated tools and repositories.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2009Article
- A dual receptor crosstalk model of G-protein-coupled signal transduction.PLoS computational biology · 2008Article
- Mechanical and biochemical modeling of cortical oscillations in spreading cells.Biophysical journal · 2008Article
- Modeling hypertrophic IP3 transients in the cardiac myocyte.Biophysical journal · 2007Article
- A signal transduction pathway model prototype II: Application to Ca2+-calmodulin signaling and myosin light chain phosphorylation.Biophysical journal · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The postgenomic era is providing a wealth of information about the genes involved in many cellular processes. However, the ability to apply this information to understanding cellular signal transduction is limited by the lack of tools that quantitatively describe cellular signaling processes. The objective of the current studies is to provide a framework for modeling cellular signaling processes beginning at a plasma membrane receptor and ending with a measurable endpoint in the signaling process. Agonist-induced Ca(2+) mobilization coupled to down stream phosphorylation events was modeled using knowledge of in vitro and in vivo process parameters. The simulation process includes several modules that describe cellular processes involving receptor activation phosphoinositide metabolism, Ca(2+)-release, and activation of a calmodulin-dependent protein kinase. A Virtual Cell-based simulation was formulated using available literature data and compared to new and existing experimental results. The model provides a new approach to facilitate hypothesis-driven investigation and experimental design based upon simulation results. These investigations may be directed at the timing of multiple phosphorylation/dephosphorylation events affecting key enzymatic activities in the signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.