ArticleProceedings of the National Academy of Sciences of the United States of America1992
Diversification of the Wnt gene family on the ancestral lineage of vertebrates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Sequence characterization and comparative expression profile of buffaloAnimal biotechnology · 2023Article
- Effects ofGenes · 2023Article
- Review
- Wnt6 is required for maxillary palp formation in Drosophila.BMC biology · 2013Article
- Comparative molecular developmental aspects of the mammalian- and the avian lungs, and the insectan tracheal system by branching morphogenesis: recent advances and future directions.Frontiers in zoology · 2012Article
- Three decades of Wnts: a personal perspective on how a scientific field developed.The EMBO journal · 2012Review
- Role of Wnt canonical pathway in hematological malignancies.Journal of hematology & oncology · 2010Review
- Phylogenetic and regulatory region analysis of Wnt5 genes reveals conservation of a regulatory module with putative implication in pancreas development.Biology direct · 2010Article
- Distinct molecular evolutionary mechanisms underlie the functional diversification of the Wnt and TGFbeta signaling pathways.Journal of molecular evolution · 2010Article
- Article
- Were vertebrates octoploid?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002Review
- Inference of functional regions in proteins by quantification of evolutionary constraints.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene.Genome research · 2001Article
- Analysis of 148 kb of genomic DNA around the wnt1 locus of Fugu rubripes.Genome research · 1999Article
- A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells.Molecular and cellular biology · 1995Article
- Molecular evolution of flower development: diversification of the plant MADS-box regulatory gene family.Genetics · 1995Article
- Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The promoter of the Xwnt-5C gene contains octamer and AP-2 motifs functional in Xenopus embryos.Nucleic acids research · 1994Article
- Wnt family proteins are secreted and associated with the cell surface.Molecular biology of the cell · 1993Article
- The fundamentals of WNT10A.Differentiation; research in biological diversityReview
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Abstract
Diversification of the Wnt genes, a family of powerful developmental regulator molecules, is inferred by molecular evolutionary analyses. Fifty-five recently determined partial sequences from a variety of vertebrates and invertebrates, together with 17 published sequences, mostly from the mouse and Drosophila melanogaster, are analyzed. Wnt-1 through -7 originated before the last common ancestor of arthropods and deuterostomes lived. Another round of gene duplication, involving Wnt-3, -5, -7, and -10, occurred after the echinoderm lineage arose, on the ancestral lineage of jawed vertebrates. Increased constraints were imposed on the Wnt genes when jawed vertebrates originated, as indicated by an overall 4-fold lower rate of amino acid replacements in jawed vertebrates compared with invertebrates and jawless vertebrates. The Wnt genes are thus inferred to have undergone a disproportionately high amount of structural and functional evolution in the relatively short time (approximately 100 million years) between the origin of the echinoderm lineage and the first diversification of jawed vertebrates. A model is presented for the relationship of functional diversification of developmental regulators and their rates of amino acid replacement.
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