Trial reportJournal of perinatology : official journal of the California Perinatal Association2005
Can oral sucrose reduce the pain and distress associated with screening for retinopathy of prematurity?
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Non-pharmacological pain relief interventions in preterm neonates undergoing screening for retinopathy of prematurity: a systematic review.BMJ open ophthalmology · 2023Pooled it
- Pooled it
- Pooled it
- Sucrose for analgesia in newborn infants undergoing painful procedures.The Cochrane database of systematic reviews · 2016Pooled it
- Effects of fentanyl and sucrose on pain in retinopathy examinations with pain scale, near-infrared spectroscopy, and ultrasonography: a randomized trial.World journal of pediatrics : WJP · 2023Trial
- Prevention of Pain During Screening for Retinopathy of Prematurity: A Randomized Control Trial Comparing Breast Milk, 10% Dextrose and Sterile Water.Indian journal of pediatrics · 2020Trial
- Effect of combined music and touch intervention on pain response and β-endorphin and cortisol concentrations in late preterm infants.BMC pediatrics · 2017Trial
- Oral Dextrose for Pain Management during Laser Treatment of Retinopathy of Prematurity under Topical Anesthesia.Indian journal of pediatrics · 2015Trial
- Oral glucose for pain relief during examination for retinopathy of prematurity: a masked randomized clinical trial.Clinics (Sao Paulo, Brazil) · 2013Trial
- Sucrose and non-nutritive sucking for the relief of pain in screening for retinopathy of prematurity: a randomised controlled trial.Archives of disease in childhood. Fetal and neonatal edition · 2006Trial
- New Directions for Ophthalmic OCT - Handhelds, Surgery, and Robotics.Translational vision science & technology · 2025Review
- Interdisciplinary collaborative eye examinations to protect preterm infant neurodevelopment: a quality improvement project.Frontiers in psychology · 2024Article
- Article
- Autonomic measures identify stress, pain, and instability associated with retinopathy of prematurity ophthalmologic examinations.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Reducing discomfort of eye drops prior to retinal examination in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Magnetic Non-invasive Auricular Acupuncture During Eye-Exam for Retinopathy of Prematurity in Preterm Infants: A Multicentre Randomized Controlled Trial.Frontiers in pediatrics · 2020Article
- Differential effects of the retinopathy of prematurity exam on the physiology of premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- N-terminal B-type natriuretic peptide urinary concentrations and retinopathy of prematurity.Pediatric research · 2017Observational
- Comparison of strategies for grading retinal images of premature infants for referral warranted retinopathy of prematurity.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2017Article
- Retinal and Optic Nerve Hemorrhages in the Newborn Infant: One-Year Results of the Newborn Eye Screen Test Study.Ophthalmology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInfants undergoing eye exams to screen for retinopathy of prematurity (ROP) demonstrate physiologic and behavioral manifestations of pain and distress. Oral sucrose has analgesic properties that might reduce these effects.
aimTo determine the efficacy of oral sucrose in reducing the pain/distress of eye exams for ROP.
methodsA total of 32 infants about to undergo ROP screening exams received either oral sucrose [S] (N=16) or sterile water [C] (N=16) in a randomized, prospective and blinded fashion. Outcome measures included HR, RR, O(2) saturation, BP, pain (premature infant pain profile) and percent of time spent crying during the eye exam.
resultsThe groups were similar in GA (weeks) (28+/-1.6), BW (kg) (1.04+/-0.26), postnatal age (days) 50.8+/-20.3, and study weight (kg) 1.88+/-0.40). Both groups demonstrated significant increases in HR, BP, and pain score in response to the exam. Infants in both groups spent the majority of time actively crying during the exam ([S] 53+/-35% vs [C] 63+/-31%. Infants receiving [S] showed a small but significant drop in O(2) saturation. No significant differences were seen between groups in physiologic or behavioral responses to the eye exam.
conclusionOral [S] was not effective in reducing pain/distress from the ROP screening exam. Alternative strategies should be considered to achieve adequate pain relief.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.