Evidence map›Paper›PMID 15342563›Full record

ArticleGenome research2004

An efficient SNP system for mouse genome scanning and elucidating strain relationships.

Petko M Petkov, Yueming Ding, Megan A Cassell, Weidong Zhang, Gunjan Wagner, Evelyn E Sargent, Steven Asquith, Victor Crew, Kevin A Johnson, Phil Robinson and 2 more

Abstract read
In one paragraph

Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Petko M PetkovThe Jackson Laboratory, Bar Harbor, Maine 04609, USA. pmp@jax.org
Yueming Ding
Megan A Cassell
Weidong Zhang
Gunjan Wagner
Evelyn E Sargent
Steven Asquith
Victor Crew
Kevin A Johnson
Phil Robinson
Valerie E Scott
Michael V Wiles

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A set of 1638 informative SNP markers easily assayed by the Amplifluor genotyping system were tested in 102 mouse strains, including the majority of the common and wild-derived inbred strains available from The Jackson Laboratory. Selected from publicly available databases, the markers are on average approximately 1.5 Mb apart and, whenever possible, represent the rare allele in at least two strains. Amplifluor assays were developed for each marker and performed on two independent DNA samples from each strain. The mean number of polymorphisms between strains was 608+/-136 SD. Several tests indicate that the markers provide an effective system for performing genome scans and quantitative trait loci analyses in all but the most closely related strains. Additionally, the markers revealed several subtle differences between closely related mouse strains, including the groups of several 129, BALB, C3H, C57, and DBA strains, and a group of wild-derived inbred strains representing several Mus musculus subspecies. Applying a neighbor-joining method to the data, we constructed a mouse strain family tree, which in most cases confirmed existing genealogies.

Indexed as

Crosses, GeneticGenetic LinkageGenomeAllelesAnimalsGenetic MarkersMiceMice, Inbred StrainsPhylogenyPolymorphism, Single NucleotideGenetic Markers

Identifiers

PMID15342563
PMCPMC515327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.