ArticleGenome research2004
Phylogenetic footprint analysis of IGF2 in extant mammals.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- The Evolutionary Advantage in Mammals of the Complementary Monoallelic Expression Mechanism of Genomic Imprinting and Its Emergence From a Defense Against the Insertion Into the Host Genome.Frontiers in genetics · 2022Review
- Role of long interspersed nuclear element-1 in the regulation of chromatin landscapes and genome dynamics.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma.Frontiers in oncology · 2013Article
- Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.BMC genomics · 2012Article
- Review
- Epigenetic mechanisms of genomic imprinting: common themes in the regulation of imprinted regions in mammals, plants, and insects.Genetics research international · 2012Article
- A phylogenetic approach to test for evidence of parental conflict or gene duplications associated with protein-encoding imprinted orthologous genes in placental mammals.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- The opossum genome: insights and opportunities from an alternative mammal.Genome research · 2008Review
- Evolution of the CDKN1C-KCNQ1 imprinted domain.BMC evolutionary biology · 2008Article
- Genomic imprinting of IGF2 in marsupials is methylation dependent.BMC genomics · 2008Article
- Characterization of the differentially methylated region of the Impact gene that exhibits Glires-specific imprinting.Genome biology · 2008Article
- The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals.BMC evolutionary biology · 2007Article
- Comparative analysis of sequence characteristics of imprinted genes in human, mouse, and cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Recent assembly of an imprinted domain from non-imprinted components.PLoS genetics · 2006Article
- Transposon-free regions in mammalian genomes.Genome research · 2006Article
- Comparative phylogenetic analysis reveals multiple non-imprinted isoforms of opossum Dlk1.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Imprinting evolution and human health.Mammalian genome : official journal of the International Mammalian Genome SocietyReview
- Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1.Mammalian genome : official journal of the International Mammalian Genome SocietyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Genomic imprinting results in monoallelic gene transcription that is directed by cis-acting regulatory elements epigenetically marked in a parent-of-origin-dependent manner. We performed phylogenetic sequence and epigenetic comparisons of IGF2 between the nonimprinted platypus (Ornithorhynchus anatinus) and imprinted opossum (Didelphis virginiana), mouse (Mus musculus), and human (Homo sapiens) to determine if their divergent imprint status would reflect differences in the conservation of genomic elements important in the regulation of imprinting. We report herein that IGF2 imprinting does not correlate evolutionarily with differential intragenic methylation, nor is it associated with motif 13, a reported IGF2-specific "imprint signature" located in the coding region. Instead, IGF2 imprinting is strongly associated with both the lack of short interspersed transposable elements (SINEs) and an intragenic conserved inverted repeat that contains candidate CTCF-binding sites, a role not previously ascribed to this particular sequence element. Our results are the first to demonstrate that comparative footprint analysis of species from evolutionarily distant mammalian clades, and exhibiting divergent imprint status is a powerful bioinformatics-based approach for identifying cis-acting elements potentially involved not only in the origins of genomic imprinting, but also in its maintenance in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.