ArticleGenome research2004
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
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- Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing.International journal of molecular sciences · 2019Review
- Porcine Models of Pancreatic Cancer.Frontiers in oncology · 2019Review
- Characterization of gene promoters in pig: conservative elements, regulatory motifs and evolutionary trend.PeerJ · 2019Article
- Nonhuman Primate Optogenetics: Recent Advances and Future Directions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation.Molecular cancer research : MCR · 2017Article
- Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies.Journal of bone and mineral metabolism · 2017Article
- A high definition look at the NF-Y regulome reveals genome-wide associations with selected transcription factors.Nucleic acids research · 2016Article
- A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma.BioMed research international · 2016Article
- Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis.The Journal of biological chemistry · 2014Article
- The novel long noncoding RNA linc00467 promotes cell survival but is down-regulated by N-Myc.PloS one · 2014Article
- Targeting the Y/CCAAT box in cancer: YB-1 (YBX1) or NF-Y?Cell death and differentiation · 2013Review
- Large-scale motif discovery using DNA Gray code and equiprobable oligomers.Bioinformatics (Oxford, England) · 2012Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Comparative sequence analysis was carried out for the regions adjacent to experimentally validated transcriptional start sites (TSSs), using 3324 pairs of human and mouse genes. We aligned the upstream putative promoter sequences over the 1-kb proximal regions and found that the sequence conservation could not be further extended at, on average, 510 bp upstream positions of the TSSs. This discontinuous manner of the sequence conservation revealed a "block" structure in about one-third of the putative promoter regions. Consistently, we also observed that G+C content and CpG frequency were significantly different inside and outside the blocks. Within the blocks, the sequence identity was uniformly 65% regardless of their length. About 90% of the previously characterized transcription factor binding sites were located within those blocks. In 46% of the blocks, the 5' ends were bounded by interspersed repetitive elements, some of which may have nucleated the genomic rearrangements. The length of the blocks was shortest in the promoters of genes encoding transcription factors and of genes whose expression patterns are brain specific, which suggests that the evolutional diversifications in the transcriptional modulations should be the most marked in these populations of genes.
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