ArticleGenetics2004
The speed of adaptation in large asexual populations.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
76 citing papers in PubMed.
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- Unveiling the Potential Role of Dhurrin in Sorghum During Infection by the Head Smut PathogenPlants (Basel, Switzerland) · 2025Article
- Genetic basis of phenotypic diversity inFrontiers in genetics · 2025Article
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- Changing fitness effects of mutations through long-term bacterial evolution.Science (New York, N.Y.) · 2024Article
- Evolvability-enhancing mutations in the fitness landscapes of an RNA and a protein.Nature communications · 2023Article
- Evolutionary Dynamics of Asexual Hypermutators Adapting to a Novel Environment.Genome biology and evolution · 2021Article
- An interplay of resource availability, population size and mutation rate potentiates the evolution of metabolic signaling.BMC ecology and evolution · 2021Article
- Microbial Experimental Evolution - a proving ground for evolutionary theory and a tool for discovery.EMBO reports · 2019Review
- Interference Effects of Deleterious and Beneficial Mutations in Large Asexual Populations.Genetics · 2019Article
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- The timetable of evolution.Science advances · 2017Review
- Dynamics of molecular evolution in RNA virus populations depend on sudden versus gradual environmental change.Evolution; international journal of organic evolution · 2017Article
- Selection Limits to Adaptive Walks on Correlated Landscapes.Genetics · 2017Article
- Stronger selection can slow down evolution driven by recombination on a smooth fitness landscape.PloS one · 2017Article
- Time-Resolved Tracking of Mutations Reveals Diverse Allele Dynamics duringFrontiers in microbiology · 2017Article
- Effect of Population Size and Mutation Rate on the Evolution of RNA Sequences on an Adaptive Landscape Determined by RNA Folding.International journal of biological sciences · 2017Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In large asexual populations, beneficial mutations have to compete with each other for fixation. Here, I derive explicit analytic expressions for the rate of substitution and the mean beneficial effect of fixed mutations, under the assumptions that the population size N is large, that the mean effect of new beneficial mutations is smaller than the mean effect of new deleterious mutations, and that new beneficial mutations are exponentially distributed. As N increases, the rate of substitution approaches a constant, which is equal to the mean effect of new beneficial mutations. The mean effect of fixed mutations continues to grow logarithmically with N. The speed of adaptation, measured as the change of log fitness over time, also grows logarithmically with N for moderately large N, and it grows double-logarithmically for extremely large N. Moreover, I derive a simple formula that determines whether at given N beneficial mutations are expected to compete with each other or go to fixation independently. Finally, I verify all results with numerical simulations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.