ArticleGenetics2004
A genetic mechanism implicates chromosome 11 in schizophrenia and bipolar diseases.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- SVhawkeye: an ultra-fast software for user-friendly visualization of targeted structural fragments from BAM files.Frontiers in genetics · 2024Article
- DRDs and Brain-Derived Neurotrophic Factor Share a Common Therapeutic Ground: A Novel Bioinformatic Approach Sheds New Light Toward Pharmacological Treatment of Cognitive and Behavioral Disorders.Advances in experimental medicine and biology · 2023Article
- A rare case of schizophrenia coexistence with antiphospholipid syndrome, β-thalassemia, and monoclonal gammopathy of undetermined significance.Frontiers in psychiatry · 2023Article
- Association Between ApoA1 Gene Polymorphisms and Antipsychotic Drug-Induced Dyslipidemia in Schizophrenia.Neuropsychiatric disease and treatment · 2021Article
- Split hand/foot malformation genetics supports the chromosome 7 copy segregation mechanism for human limb development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- A Unique DNA Recombination Mechanism of the Mating/Cell-type Switching of Fission Yeasts: a Review.Microbiology spectrum · 2014Review
- Selective chromatid segregation mechanism invoked for the human congenital mirror hand movement disorder development by RAD51 mutations: a hypothesis.International journal of biological sciences · 2014Review
- Unbiased segregation of fission yeast chromosome 2 strands to daughter cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Npas4: a neuronal transcription factor with a key role in social and cognitive functions relevant to developmental disorders.PloS one · 2012Article
- Functional characterization of stem cell activity in the mouse mammary gland.Stem cell reviews and reports · 2011Review
- Some capabilities for model-based and model-free linkage analysis using the program package S.A.G.E. (Statistical Analysis for Genetic Epidemiology).Human heredity · 2011Article
- A proposal for re-defining the way the aetiology of schizophrenia and bipolar human psychiatric diseases is investigated.Journal of biosciences · 2010Article
- Discovery of the mitotic selective chromatid segregation phenomenon and its implications for vertebrate development.Current opinion in cell biology · 2010Review
- Asymmetric strand segregation: epigenetic costs of genetic fidelity?PLoS genetics · 2009Article
- Scalp hair-whorl orientation of Japanese individuals is random; hence, the trait's distribution is not genetically determined.Seminars in cell & developmental biology · 2009Review
- Support for the selective chromatid segregation hypothesis advanced for the mechanism of left-right body axis development in mice.Breast disease · 2008Article
- Article
- A 1927 study supports a current genetic model for inheritance of human scalp hair-whorl orientation and hand-use preference traits.Genetics · 2005Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The causes of schizophrenia and bipolar human psychiatric disorders are unknown. A novel somatic cell genetic model postulated nonrandom segregation of "Watson" vs. "Crick" DNA chains of both copies of a chromosome to specific daughter cells. Such an oriented asymmetric cell division causes development of healthy, functionally nonequivalent brain hemispheres. Genetic translocations of the chromosome may cause disease by disrupting the biased strand-segregation process. Only one-half of chromosome 1 and 11 translocation carriers developing disease were recently explained as a result consistent with the model (Klar 2002). Is chromosome 1 or 11 involved? Does the translocation breakpoint cause disease? Remarkably, two other unrelated chromosome 11 translocations discovered from the literature likewise caused disease in approximately 50% of carriers. Together, their breakpoints lie at three distinct regions spanning approximately 40% of chromosome 11. Thus, chromosome 11 is implicated but the breakpoints themselves are unlikely to cause the disease. The results suggest that the genetically caused disease develops without a Mendelian gene mutation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.