ArticleGenetics2004
Enhancer choice in cis and in trans in Drosophila melanogaster: role of the promoter.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Transvection between nonallelic genomic positions in Drosophila.G3 (Bethesda, Md.) · 2024Article
- Transcriptional misexpression in hybrids between species linked by gene flow is associated with patterns of sequence divergence.Genome biology and evolution · 2023Article
- Regulation at Drosophila's Malic Enzyme highlights the complexity of transvection and its sensitivity to genetic background.Genetics · 2023Article
- Activating and repressing gene expression between chromosomes during stochastic fate specification.Cell reports · 2023Article
- Altering enhancer-promoter linear distance impacts promoter competition in cis and in trans.Genetics · 2022Article
- Article
- Position Effects Influence Transvection inGenetics · 2019Article
- The Role of Insulators in Transgene Transvection inGenetics · 2019Article
- Article
- Article
- Establishment of a Developmental Compartment Requires Interactions between Three Synergistic Cis-regulatory Modules.PLoS genetics · 2015Article
- Transvection-based gene regulation in Drosophila is a complex and plastic trait.G3 (Bethesda, Md.) · 2014Article
- The promoter activation at the end of terminally truncated chromosome in Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2014Article
- Exploring the effects of polymorphisms on cis-regulatory signal transduction response.Trends in molecular medicine · 2013Review
- Comparing enhancer action in cis and in trans.Genetics · 2012Article
- Transvection is common throughout the Drosophila genome.Genetics · 2012Article
- Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes.PLoS genetics · 2012Article
- Nonclassical regulation of transcription: interchromosomal interactions at the malic enzyme locus of Drosophila melanogaster.Genetics · 2011Article
- Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding.Nucleic acids research · 2010Article
- Effects of chromosomal rearrangements on transvection at the yellow gene of Drosophila melanogaster.Genetics · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Eukaryotic enhancers act over very long distances, yet still show remarkable specificity for their own promoter. To better understand mechanisms underlying this enhancer-promoter specificity, we used transvection to analyze enhancer choice between two promoters, one located in cis to the enhancer and the other in trans to the enhancer, at the yellow gene of Drosophila melanogaster. Previously, we demonstrated that enhancers at yellow prefer to act on the cis-linked promoter, but that mutation of core promoter elements in the cis-linked promoter releases enhancers to act in trans. Here, we address the mechanism by which these elements affect enhancer choice. We consider and explicitly test three models that are based on promoter competency, promoter pairing, and promoter identity. Through targeted gene replacement of the endogenous yellow gene, we show that competency of the cis-linked promoter is a key parameter in the cis-trans choice of an enhancer. In fact, complete replacement of the yellow promoter with both TATA-containing and TATA-less heterologous promoters maintains enhancer action in cis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.