ArticleGenetics2004
The Aspergillus nidulans npkA gene encodes a Cdc2-related kinase that genetically interacts with the UvsBATR kinase.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Dynamic Transcriptomic and Phosphoproteomic Analysis During Cell Wall Stress inMolecular & cellular proteomics : MCP · 2020Article
- Involvement of the adaptor protein 3 complex in lignocellulase secretion in Neurospora crassa revealed by comparative genomic screening.Biotechnology for biofuels · 2015Article
- Functional characterization of a new member of the Cdk9 family in Aspergillus nidulans.Eukaryotic cell · 2010Article
- The RFX protein RfxA is an essential regulator of growth and morphogenesis in Penicillium marneffei.Eukaryotic cell · 2010Article
- Differences in spontaneous mutation frequencies as a function of environmental stress in soil fungi at "Evolution Canyon," Israel.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Functional characterization of the putative Aspergillus nidulans DNA damage binding protein homologue DdbA.Molecular genetics and genomics : MGG · 2008Article
- Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway.Genetics · 2008Article
- Transcriptome analysis of Aspergillus nidulans exposed to camptothecin-induced DNA damage.Eukaryotic cell · 2006Article
- Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA.Genetics · 2006Article
- Regulation of hyphal morphogenesis and the DNA damage response by the Aspergillus nidulans ATM homolog AtmA.Genetics · 2006Article
- The csnD/csnE signalosome genes are involved in the Aspergillus nidulans DNA damage response.Genetics · 2005Article
- Aspergillus nidulans uvsBATR and scaANBS1 genes show genetic interactions during recovery from replication stress and DNA damage.Eukaryotic cell · 2005Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The DNA damage response is a protective mechanism that ensures the maintenance of genomic integrity. We have used Aspergillus nidulans as a model system to characterize the DNA damage response caused by the antitopoisomerase I drug, camptothecin. We report the molecular characterization of a p34Cdc2-related gene, npkA, from A. nidulans. The npkA gene is transcriptionally induced by camptothecin and other DNA-damaging agents, and its induction in the presence of camptothecin is dependent on the uvsBATR gene. There were no growth defects, changes in developmental patterns, increased sensitivity to DNA-damaging agents, or effects on septation or growth rate in the A. nidulans npkA deletion strain. However, the DeltanpkA mutation can partially suppress HU sensitivity caused by the DeltauvsBATR and uvsD153ATRIP checkpoint mutations. We demonstrated that the A. nidulans uvsBATR gene is involved in DNA replication and the intra-S-phase checkpoints and that the DeltanpkA mutation can suppress its intra-S-phase checkpoint deficiency. There is a defect in both the intra-S-phase and DNA replication checkpoints due to the npkA inactivation when DNA replication is slowed at 6 mm HU. Our results suggest that the npkA gene plays a role in cell cycle progression during S-phase as well as in a DNA damage signal transduction pathway in A. nidulans.
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