ArticleCerebral cortex (New York, N.Y. : 1991)2005
Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice.
Article in Cerebral cortex (New York, N.Y. : 1991), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- New Insights into Mitochondria in Health and Diseases.International journal of molecular sciences · 2024Review
- The Impact of Maternal Antioxidants on Prenatal Stress Effects on Offspring Neurobiology and Behavior.The Yale journal of biology and medicine · 2022Article
- The Role of Redox Dysregulation in the Effects of Prenatal Stress on Embryonic Interneuron Migration.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Enforced DNA repair enzymes rescue neurons from apoptosis induced by target deprivation and axotomy in mouse models of neurodegeneration.Mechanisms of ageing and development · 2017Article
- Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations.Oncotarget · 2016Article
- Evaluating the effects of bioremediation on genotoxicity of polycyclic aromatic hydrocarbon-contaminated soil using genetically engineered, higher eukaryotic cell lines.Environmental science & technology · 2012Article
- Mitochondria: in sickness and in health.Cell · 2012Review
- Oxidative DNA damage in neurons: implication of ku in neuronal homeostasis and survival.International journal of cell biology · 2012Article
- Article
- UVB suppresses PTEN expression by upregulating miR-141 in HaCaT cells.Journal of biomedical research · 2011Article
- Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2009Article
- Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities.Antioxidants & redox signaling · 2009Review
- Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis.The EMBO journal · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
DNA repair plays a critical, but imprecisely defined role in neuronal survival during cortical neurogenesis. We examined cortical development in mice deficient for the DNA end-joining protein, Ku70. At gestational day 14.5, corresponding to the peak of neurogenesis, the Ku70(-/-) embryonic cerebral cortex displayed 25- to 30-fold more cell death than heterozygous littermates, as judged by DNA breaks, pyknosis and active caspase-3. In Ku70(-/-) embryos only, large clusters of dying neurons were found in the intermediate zone. Cell death declined until P4, when the number of dying cells became comparable to that in heterozygous mice. Two groups of dying cells were evident: a GLAST(+) neural progenitor population in the subventricular and ventricular zones, and a doublecortin(+) immature neuron population in the intermediate zone, the latter exhibiting strong staining for oxidative DNA damage. Antioxidants and lower oxygen tension reduced the high levels of neuronal death in primary cortical cultures derived from Ku70(-/-) mice, but not the low levels of cell death in wildtype cortical cultures. Results indicate migrating cortical neurons undergo oxidative DNA damage, which is normally repaired by non-homologous end joining. Failure to repair oxidative damage triggers a form of apoptosis involving caspase-3 activation.
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