ArticleInfection and immunity1992
Recognition of Leishmania antigens by T lymphocytes from nonexposed individuals.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- Nivolumab EnhancesFrontiers in immunology · 2017Article
- Identifying vaccine targets for anti-leishmanial vaccine development.Expert review of vaccines · 2014Review
- Clinical and Immunological Analysis of Cutaneous Leishmaniasis before and after Different Treatments.Journal of parasitology research · 2013Article
- Diagnostic techniques to detect cryptic leishmaniasis in dogs.Clinical and diagnostic laboratory immunology · 2002Article
- Differential induction of cellular responses by live and dead Leishmania promastigotes in healthy donors.Clinical and experimental immunology · 2001Article
- The Leishmania infantum acidic ribosomal protein LiP2a induces a prominent humoral response in vivo and stimulates cell proliferation in vitro and interferon-gamma (IFN-gamma) production by murine splenocytes.Clinical and experimental immunology · 2000Article
- Leishmania-specific T cells expressing interferon-gamma (IFN-gamma) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis.Clinical and experimental immunology · 1999Article
- DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells.Infection and immunity · 1998Article
- Trypanosome variant surface glycoproteins are recognized by self-reactive antibodies in uninfected hosts.Infection and immunity · 1996Article
- Article
- Reactive arthritis-associated bacteria can stimulate lymphocyte proliferation in non-exposed individuals and newborns.Clinical and experimental immunology · 1995Article
- Dichotomy of the T cell response to Leishmania antigens in patients suffering from cutaneous leishmaniasis; absence or scarcity of Th1 activity is associated with severe infections.Clinical and experimental immunology · 1995Article
- Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients.Clinical and experimental immunology · 1994Article
- Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis.Clinical and experimental immunology · 1994Article
- Increased plasma levels of soluble IL-2R are associated with severe Plasmodium falciparum malaria.Clinical and experimental immunology · 1994Article
- Natural and acquired resistance to Leishmania: cellular activation by Leishmania aethiopica of mononuclear cells from unexposed individuals is through the stimulation of natural killer (NK) cells.Clinical and experimental immunology · 1993Article
- T-cell responses to highly conserved CD4 and CD8 epitopes on the outer membrane protein of bovine leukemia virus: relevance to vaccine development.Journal of virology · 1993Article
- Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis.Infection and immunity · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crude antigen preparations of Leishmania promastigote sonicates were found to induce in vitro proliferation and gamma interferon production in peripheral blood mononuclear cells (PBMC) from individuals without known exposure to the parasite. The proliferating cells were mainly CD2-positive T cells. The proliferative response was maximal after more than 6 days of incubation with the antigens in contrast to the proliferation induced by the mitogenic lectin phytohemagglutinin (PHA), which peaked after 3 to 5 days. Judged by limiting dilution analysis, the frequencies of antigen-reactive precursor cells were less than 1:10,000 and varied considerably between individuals. Depletion of CD45R0-positive (memory) cells from the PBMC abolished proliferative responses induced by Leishmania antigen and by tetanus toxoid. In cell populations depleted of CD45RA-positive (naive) cells, only a small reduction in response was observed. Cell populations depleted of either CD45R0-positive cells or CD45RA-positive cells both responded to PHA. We conclude that presumably unexposed individuals have a low number of Leishmania-reactive T cells in their circulatory systems. The Leishmania-reactive T cells in these individuals are most likely memory cells recognizing antigens present both in the Leishmania preparations and in the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.