ArticleNature biotechnology2004
Monitoring and modeling horizontal gene transfer.
Article in Nature biotechnology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Biofilms: hot spots of horizontal gene transfer (HGT) in aquatic environments, with a focus on a new HGT mechanism.FEMS microbiology ecology · 2020Review
- Recording mobile DNA in the gut microbiota using an Escherichia coli CRISPR-Cas spacer acquisition platform.Nature communications · 2020Article
- Cell-Free DNA: An Underestimated Source of Antibiotic Resistance Gene Dissemination at the Interface Between Human Activities and Downstream Environments in the Context of Wastewater Reuse.Frontiers in microbiology · 2020Review
- Mathematical model predicts anti-adhesion-antibiotic-debridement combination therapies can clear an antibiotic resistant infection.PLoS computational biology · 2019Article
- Modeling Multispecies Gene Flow Dynamics Reveals the Unique Roles of Different Horizontal Gene Transfer Mechanisms.Frontiers in microbiology · 2018Article
- Article
- Results from the Workshop "Problem Formulation for the Use of Gene Drive in Mosquitoes".The American journal of tropical medicine and hygiene · 2017Article
- Detecting rare gene transfer events in bacterial populations.Frontiers in microbiology · 2014Review
- Bacterial natural transformation by highly fragmented and damaged DNA.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Horizontal gene transfer dynamics and distribution of fitness effects during microbial in silico evolution.BMC bioinformatics · 2012Article
- An investigation of horizontal transfer of feed introduced DNA to the aerobic microbiota of the gastrointestinal tract of rats.BMC research notes · 2012Article
- Assessing the probability of detection of horizontal gene transfer events in bacterial populations.Frontiers in microbiology · 2012Article
- Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures.The Journal of antimicrobial chemotherapy · 2011Article
- Development of real time PCR assays for detection and quantification of transgene DNA of a Bacillus thuringiensis (Bt) corn hybrid in soil samples.Transgenic research · 2010Article
- Article
- Transgenic hybrid aspen overexpressing the Atwbc19 gene encoding an ATP-binding cassette transporter confers resistance to four aminoglycoside antibiotics.Plant cell reports · 2010Article
- Article
- Visual evidence of horizontal gene transfer between plants and bacteria in the phytosphere of transplastomic tobacco.Applied and environmental microbiology · 2009Article
- Genomic islands: tools of bacterial horizontal gene transfer and evolution.FEMS microbiology reviews · 2009Review
- Impact of cry1AC-carrying Brassica rapa subsp. pekinensis on leaf bacterial community.Journal of microbiology (Seoul, Korea) · 2009Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monitoring efforts have failed to identify horizontal gene transfer (HGT) events occurring from transgenic plants into bacterial communities in soil or intestinal environments. The lack of such observations is frequently cited in biosafety literature and by regulatory risk assessment. Our analysis of the sensitivity of current monitoring efforts shows that studies to date have examined potential HGT events occurring in less than 2 g of sample material, when combined. Moreover, a population genetic model predicts that rare bacterial transformants acquiring transgenes require years of growth to out-compete wild-type bacteria. Time of sampling is there-fore crucial to the useful implementation of monitoring. A population genetic approach is advocated for elucidating the necessary sample sizes and times of sampling for monitoring HGT into large bacterial populations. Major changes in current monitoring approaches are needed, including explicit consideration of the population size of exposed bacteria, the bacterial generation time, the strength of selection acting on the transgene-carrying bacteria, and the sample size necessary to verify or falsify the HGT hypotheses tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.