ArticleMolecular and cellular biology2004
Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- The p38 Pathway: From Biology to Cancer Therapy.International journal of molecular sciences · 2020Review
- Functional interactions between Mi-2β and AP1 complexes control response and recovery from skin barrier disruption.The Journal of experimental medicine · 2020Article
- Unexpected dose response of HaCaT to UVB irradiation.In vitro cellular & developmental biology. Animal · 2018Article
- T Cell Leukemia/Lymphoma 1A is essential for mouse epidermal keratinocytes proliferation promoted by insulin-like growth factor 1.PloS one · 2018Article
- Insights into gene expression profiles induced by Socs3 depletion in keratinocytes.Scientific reports · 2017Article
- Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-Cells.International journal of molecular sciences · 2016Review
- Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease.Pharmacology & therapeutics · 2016Review
- MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling.The Journal of investigative dermatology · 2016Article
- Methylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene Expression.The Journal of biological chemistry · 2015Article
- Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype.The Journal of investigative dermatology · 2015Article
- Host defense (Antimicrobial) peptide, human β-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes.The Journal of investigative dermatology · 2014Article
- p38δ regulates p53 to control p21Cip1 expression in human epidermal keratinocytes.The Journal of biological chemistry · 2014Article
- p38δ MAPK: Emerging Roles of a Neglected Isoform.International journal of cell biology · 2014Review
- Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth.International journal of oncology · 2013Article
- Protein kinase C δ increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes.The Journal of biological chemistry · 2013Article
- AP1 transcription factors in epidermal differentiation and skin cancer.Journal of skin cancer · 2013Article
- IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.The Journal of clinical investigation · 2012Article
- Heterogeneity in apoptotic responses of microvascular endothelial cells to oxidative stress.Journal of cellular physiology · 2012Article
- Protein arginine methyltransferase 5 (PRMT5) signaling suppresses protein kinase Cδ- and p38δ-dependent signaling and keratinocyte differentiation.The Journal of biological chemistry · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Protein kinase Cdelta (PKCdelta) is an important regulator of apoptosis in epidermal keratinocytes. However, little information is available regarding the downstream kinases that mediate PKCdelta-dependent keratinocyte death. This study implicates p38delta mitogen-activated protein kinase (MAPK) as a downstream carrier of the PKCdelta-dependent death signal. We show that coexpression of PKCdelta with p38delta produces profound apoptosis-like morphological changes. These morphological changes are associated with increased sub-G(1) cell population, cytochrome c release, loss of mitochondrial membrane potential, caspase activation, and PARP cleavage. This death response is specific for the combination of PKCdelta and p38delta and is not produced by replacing PKCdelta with PKCalpha or p38delta with p38alpha. A constitutively active form of MEK6, an upstream activator of p38delta, can also produce cell death when coupled with p38delta. In addition, concurrent p38delta activation and extracellular signal-regulated kinase 1/2 (ERK1/2) inactivation are required for apoptosis. Regarding this inverse regulation, we describe a p38delta-ERK1/2 complex that may coordinate these changes in activity. We further show that this p38delta-ERK1/2 complex relocates into the nucleus in response to PKCdelta expression. This regulation appears to be physiological, since H(2)O(2), a known inducer of keratinocyte apoptosis, promotes identical PKCdelta and p38delta-ERK1/2 activity changes, leading to similar morphological changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.