ArticleMolecular and cellular biology2004
Unexpectedly complex editing patterns at dinucleotide insertion sites in Physarum mitochondria.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Structural divergence and molecular adaptation ofFrontiers in plant science · 2026Article
- Comparative organelle genomics in Daphniphyllaceae reveal phylogenetic position and organelle structure evolution.BMC genomics · 2025Article
- Article
- Mitochondrial and plastid genome architecture: Reoccurring themes, but significant differences at the extremes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A survey of PPR proteins identifies DYW domains like those of land plant RNA editing factors in diverse eukaryotes.RNA biology · 2013Article
- Complete characterization of the edited transcriptome of the mitochondrion of Physarum polycephalum using deep sequencing of RNA.Nucleic acids research · 2011Article
- When you can't trust the DNA: RNA editing changes transcript sequences.Cellular and molecular life sciences : CMLS · 2011Review
- Abundant 5S rRNA-like transcripts encoded by the mitochondrial genome in amoebozoa.Eukaryotic cell · 2010Article
- RNA editing of 10 Didymium iridis mitochondrial genes and comparison with the homologous genes in Physarum polycephalum.RNA (New York, N.Y.) · 2010Article
- Organization and expression of organellar genomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Two forms of RNA editing are required for tRNA maturation in Physarum mitochondria.RNA (New York, N.Y.) · 2010Article
- Distinct roles for sequences upstream of and downstream from Physarum editing sites.RNA (New York, N.Y.) · 2009Article
- Non-DNA-templated addition of nucleotides to the 3' end of RNAs by the mitochondrial RNA polymerase of Physarum polycephalum.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Many of the RNAs transcribed from the mitochondrial genome of Physarum polycephalum are edited by the insertion of nonencoded nucleotides, which are added either singly or as dinucleotides. In addition, at least one mRNA is also subject to substitutional editing in which encoded C residues are changed to U residues posttranscriptionally. We have shown previously that the predominant type of editing in these organelles, the insertion of nonencoded single C residues, occurs cotranscriptionally at the growing end of the RNA chain. However, less is known about the timing of dinucleotide addition, and it has been suggested that these insertions occur at a later stage in RNA maturation. Here we examine the addition of both single nucleotides and dinucleotides into nascent RNAs synthesized in vitro and in vivo. The distribution of added nucleotides within individual cloned cDNAs supports the hypothesis that all insertion sites are processed at the same time relative to transcription. In addition, the patterns of partial editing and misediting observed within these nascent RNAs suggest that separate factors may be required at a subset of dinucleotide insertion sites and raise the possibility that in vivo, nucleotides may be added to RNA and then changed posttranscriptionally.
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