ArticleBiophysical journal2004
Topographical pattern dynamics in passive adhesion of cell membranes.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Real-Time Binding Kinetics of Small Molecules to CA IX in Live Suspension Cells Using SPR Microscopy.ACS medicinal chemistry letters · 2026Article
- Concentration Dependent Effect of Quaternary Amines on the Adhesion of U251-MG Cells.Gels (Basel, Switzerland) · 2022Article
- Mechanisms of frustrated phagocytic spreading of human neutrophils on antibody-coated surfaces.Biophysical journal · 2022Article
- Label-free and live cell imaging by interferometric scattering microscopy.Chemical science · 2018Article
- Investigation of red blood cell mechanical properties using AFM indentation and coarse-grained particle method.Biomedical engineering online · 2017Article
- HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity.Nature structural & molecular biology · 2017Article
- Cell Adhesion on Amyloid Fibrils Lacking Integrin Recognition Motif.The Journal of biological chemistry · 2016Article
- Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes.Biochimica et biophysica acta · 2013Article
- The influence of inhomogeneous adhesion on the detachment dynamics of adhering cells.European biophysics journal : EBJ · 2013Article
- Adhesion-induced phase behavior of two-component membranes and vesicles.International journal of molecular sciences · 2013Article
- Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images.Nano letters · 2013Article
- Prevention of pleural adhesions by bioactive polypeptides - a pilot study.International journal of medical sciences · 2013Article
- Analysis of initial cell spreading using mechanistic contact formulations for a deformable cell model.PLoS computational biology · 2013Article
- Optimal poly(L-lysine) grafting density in hydrogels for promoting neural progenitor cell functions.Biomacromolecules · 2012Article
- Differential dynamics of platelet contact and spreading.Biophysical journal · 2012Article
- Homeostasis of extracellular ATP in human erythrocytes.The Journal of biological chemistry · 2011Article
- Febrile temperature leads to significant stiffening of Plasmodium falciparum parasitized erythrocytes.American journal of physiology. Cell physiology · 2009Article
- Adhesion molecule-modified biomaterials for neural tissue engineering.Frontiers in neuroengineering · 2009Article
- Physical model for membrane protrusions during spreading.Physical biology · 2008Article
- Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strong adhesion of highly active cells often nucleates focal adhesions, synapses, and related structures. Red cells lack such complex adhesion systems and are also nonmotile, but they are shown here to dynamically evolve complex spatial patterns beyond an electrostatic threshold for strong adhesion. Spreading of the cell onto a dense, homogeneous poly-L-lysine surface appears complete in <1 s with occasional blisters that form and dissipate on a similar timescale; distinct rippled or stippled patterns in fluorescently labeled membrane components emerge later, however, on timescales more typical of long-range lipid diffusion (approximately minutes). Within the contact zone, the anionic fluorescent lipid fluorescein phosphoethanolamine is seen to rearrange, forming worm-like rippled or stippled domains of <500 nm that prove independent of whether the cell is intact and sustaining a tension or ruptured. Lipid patterns are accompanied by visible perturbations in Band 3 distribution and weaker perturbations in membrane skeleton actin. Pressing down on the membrane quenches the lipid patterns, revealing a clear topographical basis for pattern formation. Counterion screening and membrane fluctuations likely contribute, but the results primarily highlight the fact that even in adhesion of a passive red cell, regions of strong contact slowly evolve to become interspersed with regions where the membrane is more distant from the surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.