ReviewJournal of molecular histology2004
Laminin-5 in epithelial tumour invasion.
Review in Journal of molecular histology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 87 citations in OpenAlex.
- Laminin 332 expression in breast carcinoma.Applied immunohistochemistry & molecular morphology : AIMM · 2012Trial
- Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics.Respiratory research · 2005Trial
- Aberrant expression and subcellular localization of laminin 332 in oral squamous cell carcinoma: Implications for invasive front assessment.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer.World journal of gastroenterology · 2024Article
- The Extracellular Matrix: A Key Accomplice of Cancer Stem Cell Migration, Metastasis Formation, and Drug Resistance in PDAC.Cancers · 2022Review
- Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021Review
- Collective cancer cell invasion requires RNA accumulation at the invasive front.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Expression of Laminin γ2 Proteolytic Fragments in Murine Skin Following Exposure to Sulfur Mustard.Anatomical record (Hoboken, N.J. : 2007) · 2020Article
- Highly sensitive detection of invasive lung cancer cells by novel antibody against amino-terminal domain of laminin γ2 chain.Cancer science · 2016Article
- SPR imaging biosensor for determination of laminin-5 as a potential cancer marker in biological material.Analytical and bioanalytical chemistry · 2016Article
- Urinary laminin-γ2 is a novel biomarker of non-muscle invasive urothelial carcinoma.Cancer science · 2015Article
- E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade.Human molecular genetics · 2015Article
- Amino-terminal fragments of laminin γ2 chain stimulate migration of metastatic breast cancer cells by interacting with CD44.Clinical & experimental metastasis · 2015Article
- Immunohistochemical analysis of laminin expression in adenoid cystic carcinoma.Journal of oral and maxillofacial pathology : JOMFP · 2014Article
- Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5).Clinical & experimental metastasis · 2014Article
- Amino-terminal fragments of laminin γ2 chain retract vascular endothelial cells and increase vascular permeability.Cancer science · 2014Article
- Article
- Expression of the gamma 2 chain of laminin-332 in eutopic and ectopic endometrium of patients with endometriosis.Reproductive biology and endocrinology : RB&E · 2013Article
- Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma.Oncotarget · 2012Article
- Genome-wide expressions in autologous eutopic and ectopic endometrium of fertile women with endometriosis.Reproductive biology and endocrinology : RB&E · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laminin-5 (LN-5), consisting of alpha3-, beta3-, and gamma2-chains, is a component of the cell adhesion complex containing hemidesmosomes and anchoring fibrils. This protein is a major constituent of the extracellular matrix and has recently proved to be an invasion marker for epithelial cells in many immunohistochemical surveys, indicating that it is frequently expressed in the invading edges of epithelial tumour cells. Additionally, intracellular accumulation of monomeric gamma2-chains has been widely observed in the invasive carcinoma cells, but its mechanism was not entirely understood. Epithelial carcinoma cells prefer to adhere onto the LN-5-rich basement membranes using the specific integrins as receptors. Induction of cell migration is an important function of LN-5 and the enhanced activity is observed in its truncated form after proteolytic shedding of the N-terminal fragments of gamma2-chains. This processing was demonstrated to be mediated mainly by several kinds of matrix metalloproteinases. The degraded fragments of gamma2-chains, released from invading carcinomas, can be immunodetected in biological fluids and potentially utilized in the clinical diagnosis of various epithelial cancers. Here, we summarize the previous clinical investigations of LN-5 in epithelial tumour progression, and also discuss what it can regulate in the cell physiological events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.