ReviewJournal of molecular histology2004
IGF-I receptor, cell-cell adhesion, tumour development and progression.
Review in Journal of molecular histology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities.Frontiers in endocrinology · 2024Review
- Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells.Cancer science · 2017Article
- Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients.Molecular and clinical oncology · 2015Article
- Cross-Talk between Adiponectin and IGF-IR in Breast Cancer.Frontiers in oncology · 2015Review
- MicroRNA-320a suppresses in GBM patients and modulates glioma cell functions by targeting IGF-1R.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Estrogen receptor beta binds Sp1 and recruits a corepressor complex to the estrogen receptor alpha gene promoter.Breast cancer research and treatment · 2012Article
- IGF-IR in patients with advanced colorectal cancer in correlation with certain clinico-morphological factors: Initial report.Oncology letters · 2011Article
- In vivo and in vitro evidence that PPARγ ligands are antagonists of leptin signaling in breast cancer.The American journal of pathology · 2011Article
- Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.Endocrine reviews · 2009Review
- PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response.Oncogene · 2007Article
- Expression of IGF-I, IGF-II, and IGF-IR in gallbladder carcinoma. A systematic analysis including primary and corresponding metastatic tumours.Journal of clinical pathology · 2006Article
- Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insulin-like growth factor I receptor (IGF-IR) has been implicated in the development and progression of many common cancers and other neoplastic diseases. The tumorigenic potential of IGF-IR relies on its antiapoptotic and transforming activities. The molecular mechanisms by which IGF-IR controls the proliferation and survival of tumour cells have been extensively studied and many pathways have been delineated. However, the role of IGF-IR in the regulation of non-mitogenic cell functions is less well understood. Here we focus on IGF-IR-dependent cell-cell adhesion. Limited studies suggested that IGF-IR can regulate cell aggregation and intercellular adhesion mediated by cadherins and cadherin-associated proteins. We review the mechanisms of this process and discuss the impact of IGF-IR-dependent cell-cell adhesion on the phenotype of tumour cells.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.