ArticleHuman genetics2004
A longitudinal study of X-inactivation ratio in human females.
Article in Human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events.Biology of sex differences · 2023Article
- X-chromosome inactivation patterns depend on age and tissue but not conception method in humans.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- Use of theGenes · 2022Article
- Low-frequency somatic copy number alterations in normal human lymphocytes revealed by large-scale single-cell whole-genome profiling.Genome research · 2022Article
- Dosage Compensation in Females with X-Linked Metabolic Disorders.International journal of molecular sciences · 2021Review
- Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women.Scientific reports · 2021Article
- Intelligence Quotient Variability in Klinefelter Syndrome Is Associated With GTPBP6 Expression Under Regulation of X-Chromosome Inactivation Pattern.Frontiers in genetics · 2021Article
- Molecular signatures of X chromosome inactivation and associations with clinical outcomes in epithelial ovarian cancer.Human molecular genetics · 2019Article
- Skewed X-inactivation is common in the general female population.European journal of human genetics : EJHG · 2019Article
- Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil.Stem cells (Dayton, Ohio) · 2018Review
- Sex disparity in cancer: roles of microRNAs and related functional players.Cell death and differentiation · 2018Review
- The More Similar, the Healthier: The Effect of Perceived Parent-Child Facial Resemblance on Parental Physical Health.Frontiers in psychology · 2018Article
- Buccal swab as a reliable predictor for X inactivation ratio in inaccessible tissues.Journal of medical genetics · 2015Article
- Article
- Sexual dimorphism in autoimmunity.The Journal of clinical investigation · 2015Review
- Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Human X-chromosome inactivation pattern distributions fit a model of genetically influenced choice better than models of completely random choice.European journal of human genetics : EJHG · 2013Article
- The epigenetic lorax: gene-environment interactions in human health.Epigenomics · 2012Review
- DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?BMC medical genomics · 2012Article
- Skewed X inactivation and survival: a 13-year follow-up study of elderly twins and singletons.European journal of human genetics : EJHG · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
Abstract
We investigated the effect of aging on X chromosome inactivation by performing a longitudinal study in a population of 178 normal females. We examined X-inactivation ratios (fraction of cells with the same X chromosome active) in two sets of peripheral blood DNA samples collected about two decades apart. We observed a strong correlation between the ratios of individual females at the two time points and found no significant difference between the two sets of measurements. These observations indicate that aging, per se (as opposed to being "aged"), has little effect on X-inactivation. However, we also found that several females who were older than 60 years of age at the time of the first measurement acquired significant changes in the X-inactivation ratio. We speculate that, if X-inactivation skewing is a frequently acquired trait in older females, it is acquired as the result of a discontinuous or catastrophic process and is not the result of constant selection for or against hematopoietic stem cells with a particular X chromosome active.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.