ArticleChromosoma2004
Correlation of meiotic events in testis sections and microspreads of mouse spermatocytes relative to the mid-pachytene checkpoint.
Article in Chromosoma, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Meiotic chromatin-associated HSF5 is indispensable for pachynema progression and male fertility.Nucleic acids research · 2024Article
- The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots.Cellular and molecular life sciences : CMLS · 2023Article
- SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis.Nucleic acids research · 2022Article
- NANOS3 suppresses premature spermatogonial differentiation to expand progenitors and fine-tunes spermatogenesis in mice.Biology open · 2022Article
- Epigenetic Dysregulation of Mammalian Male Meiosis Caused by Interference of Recombination and Synapsis.Cells · 2021Article
- Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermia.Reproductive biology and endocrinology : RB&E · 2021Article
- A novel function for CDK2 activity at meiotic crossover sites.PLoS biology · 2020Article
- Transition from a meiotic to a somatic-like DNA damage response during the pachytene stage in mouse meiosis.PLoS genetics · 2019Article
- Article
- Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Alterations in chromosomal synapses and DNA repair in apoptotic spermatocytes of Mus m. domesticus.European journal of histochemistry : EJH · 2016Article
- Robertsonian translocations modify genomic distribution of γH2AFX and H3.3 in mouse germ cells.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Chromosome aberrations and spermatogenic disorders in mice with Robertsonian translocation (11; 13).International journal of clinical and experimental pathology · 2014Article
- Recombination and synaptic adjustment in oocytes of mice heterozygous for a large paracentric inversion.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Article
- Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis.PLoS genetics · 2013Article
- Dynamics of response to asynapsis and meiotic silencing in spermatocytes from Robertsonian translocation carriers.PloS one · 2013Article
- Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways.Cellular and molecular life sciences : CMLS · 2012Review
- Inactivation or non-reactivation: what accounts better for the silence of sex chromosomes during mammalian male meiosis?Chromosoma · 2012Article
- Human male meiotic sex chromosome inactivation.PloS one · 2012Article
- Cul4A is essential for spermatogenesis and male fertility.Developmental biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
In mouse, asynaptic meiotic mutants arrest at Testis Epithelial Stage IV. This arrest is 4.5 days after homologous chromosomes begin to synapse and approximately 2.5 days after synapsis is usually completed. To correlate cytological events with meiotic progression in testis and to determine which meiotic events are normally completed by Stage IV, we induced spermatogenic arrest by placing mice on a vitamin A deficient diet. Subsequent injection of retinoic acid and a return to a normal diet resulted in resumption of spermatogenesis with all spermatocytes proceeding through meiosis in a highly synchronous cohort. Between Days 11 and 16 post-injection we prepared one testis for immunocytological and the other for histological evaluation, then used antibodies to SCP3 and either RPA, or MLH1 to follow quantitative changes in synapsis and recombination. RPA was found at sites along the synaptonemal complex as soon as homologs synapsed, and most, but not all, RPA disappeared by Stage IV. MLH1 foci appeared between Stage II and IV and remained through Stage VII, the end point of the study. The data suggest that the earliest the mid-pachytene checkpoint can be activated is Epithelial Stage IV, but that activities monitored by the checkpoint may not be completed by this time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.