ArticleIntensive care medicine2004
Effects of thoracic epidural anaesthesia on intestinal microvascular perfusion in a rodent model of normotensive endotoxaemia.
Article in Intensive care medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial.Critical care (London, England) · 2013Trial
- Spinal anesthesia alleviates dextran sodium sulfate-induced colitis by modulating the gut microbiota.World journal of gastroenterology · 2022Article
- Neuraxial Regional Anaesthesia in Patients with Active Infection and Sepsis: A Clinical Narrative Review.Turkish journal of anaesthesiology and reanimation · 2018Review
- Thoracic epidural anesthesia: Effects on splanchnic circulation and implications in Anesthesia and Intensive care.World journal of critical care medicine · 2015Article
- Anesthesia for patients with liver disease.Hepatitis monthly · 2014Review
- Thoracic epidural anesthesia decreases endotoxin-induced endothelial injury.BMC anesthesiology · 2014Article
- Perioperative care in perforation peritonitis: Where do we stand?Journal of anaesthesiology, clinical pharmacology · 2013Article
- Intra-abdominal hypertension in patients with sellar region tumors.Annals of intensive care · 2012Article
- Anesthesia and perioperative management of colorectal surgical patients - specific issues (part 2).Journal of anaesthesiology, clinical pharmacology · 2012Article
- Year in review 2009: Critical Care--shock.Critical care (London, England) · 2010Review
- Thoracic epidural anesthesia reverses sepsis-induced hepatic hyperperfusion and reduces leukocyte adhesion in septic rats.Critical care (London, England) · 2009Article
- Epidural analgesia in sepsis: too early to judge a new concept.Intensive care medicine · 2004Article
- Thoracic epidural block in sepsis: Looking beyond the known.Journal of anaesthesiology, clinical pharmacologyArticle
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether sympathetic blockade by means of thoracic epidural anaesthesia (TEA) increases intestinal perfusion during normotensive endotoxaemia.
designA prospective, randomised and controlled animal study.
settingAnimal laboratory in a university hospital. SUBJECTS: Sprague-Dawley male rats.
interventionsThe rats were anaesthetised with urethane and ketamine, mechanically ventilated and haemodynamically monitored. Lidocaine or saline were infused continuously via thoracic epidural catheters followed by a continuous intravenous infusion of Escherichia coli lipopolysaccharide (1.5 mg/kg per h). Densities of perfused and non-perfused capillaries (i.e., with and without erythrocyte perfusion, respectively) as well as erythrocyte velocity in both the mucosa and the muscularis of the terminal ileum were determined using intravital microscopy. MEASUREMENTS AND
resultsMeasurements were performed at baseline, after 30 min of epidural infusion as well as after 60 and 120 min of lipopolysaccharide infusion. In animals receiving TEA, mean arterial pressure and heart rate were significantly reduced throughout the experiment. In the muscularis the endotoxaemia-induced increase in non-perfused capillaries was absent with epidural lidocaine (0 [0/0] versus 39 [36/137] cm(-1), median [25(th)/75(th) percentile]), whereas in the mucosa perfused capillary density declined to a greater extent than in controls (-47 [-53/-23]%) versus -19 [-34/+10]%, p<0.05). Erythrocyte velocity decreased with endotoxaemia and was not influenced by epidural lidocaine.
conclusionsMicrovascular perfusion data during endotoxaemia show a redistribution of blood flow towards the mucosa. TEA seems to impede this redistribution resulting in improved muscularis and worsened mucosal microvascular perfusion.
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