ArticleImmunogenetics2004
Fugu immunoglobulin D: a highly unusual gene with unprecedented duplications in its constant region.
Article in Immunogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 108 citations in OpenAlex.
- Systematic characterization of immunoglobulin loci and deep sequencing of the expressed repertoire in the Atlantic cod (Gadus morhua).BMC genomics · 2024Article
- A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons.BMC immunology · 2023Article
- Expression analysis of Igs and mucosal immune responses upon SVCV infection in common carp (Fish and shellfish immunology reports · 2022Article
- Current status and development prospects of aquatic vaccines.Frontiers in immunology · 2022Review
- Mucosal immunoglobulins of teleost fish: A decade of advances.Developmental and comparative immunology · 2021Review
- A long reads-based de-novo assembly of the genome of the Arlee homozygous line reveals chromosomal rearrangements in rainbow trout.G3 (Bethesda, Md.) · 2021Article
- Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection.PLoS pathogens · 2018Article
- Molecular Cloning and Expression Analysis of IgD in Nile Tilapia (Oreochromis niloticus) in Response to Streptococcus agalactiae Stimulus.International journal of molecular sciences · 2016Article
- Characterization of the torafugu (Takifugu rubripes) immunoglobulin heavy chain gene locus.Immunogenetics · 2015Article
- Spatio-temporal expression of blunt snout bream (Megalobrama amblycephala) mIgD and its immune response to Aeromonas hydrophila.Central-European journal of immunology · 2015Article
- Genome complexity in the coelacanth is reflected in its adaptive immune system.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014Article
- The astonishing diversity of Ig classes and B cell repertoires in teleost fish.Frontiers in immunology · 2013Article
- Mucosal immunoglobulins and B cells of teleost fish.Developmental and comparative immunology · 2011Review
- Salmonid T cells assemble in the thymus, spleen and in novel interbranchial lymphoid tissue.Journal of anatomy · 2010Article
- Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar.BMC genomics · 2010Article
- New insights into the enigma of immunoglobulin D.Immunological reviews · 2010Review
- Structure of the catfish IGH locus: analysis of the region including the single functional IGHM gene.Immunogenetics · 2006Article
- IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- The plasticity of immunoglobulin gene systems in evolution.Immunological reviews · 2006Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated and characterized the cDNA that encodes IgD of fugu (Takifugu rubripes). Though the splicing of micro1 with the delta1 domain was similar to those reported for teleost IgDs, highly unusual and unprecedented domain duplications were found in the constant region of the fugu IgD. The structure of the fugu IgD is like VDJ-micro1-(delta1-delta2-delta3-delta4-delta5-delta6)(2)-delta7-deltam1-deltam2. Genomic sequence analysis of the fugu IgD gene supported the results of cDNA sequencing that the first six delta domains in the constant region are duplicated. Such a novel duplication pattern has not been reported in any other vertebrates. However, IgD secretory domains could not be identified in this study. The deduced amino acid sequence of the fugu IgD constant region showed high identity (35-55%) to the sequences of previously reported teleost IgDs. Gene expression analyses based on RT-PCR demonstrated that the IgD gene is preferentially expressed in presumptive lymphoid tissues; moreover, in situ hybridization showed that IgD-positive cells are distributed throughout the spleen and head kidney. The expression pattern is similar to that of IgM, corroborating the hypothesis that IgD plays an important role in the humoral immune system of this species.
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