ArticleThe Journal of experimental medicine2004
Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri.
Article in The Journal of experimental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease.Signal transduction and targeted therapy · 2025Review
- Unraveling clonal CD8 T cell expansion and identification of essential factors in γ-herpesvirus-induced lymphomagenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Wildebeest-Derived Malignant Catarrhal Fever: A Bovine Peripheral T Cell Lymphoma Caused by Cross-Species Transmission ofViruses · 2023Review
- Masters of manipulation: Viral modulation of the immunological synapse.Cellular microbiology · 2018Review
- The Modulation of Apoptotic Pathways by Gammaherpesviruses.Frontiers in microbiology · 2016Review
- Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri.Journal of immunology research · 2015Article
- Article
- Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases.Leukemia · 2012Article
- Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide.Journal of virology · 2012Article
- Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation.The Journal of biological chemistry · 2012Article
- Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip.Cell communication and signaling : CCS · 2012Article
- Activation of the STAT6 transcription factor in Jurkat T-cells by the herpesvirus saimiri Tip protein.The Journal of general virology · 2012Article
- A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip.PloS one · 2012Article
- Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation.Journal of virology · 2011Article
- Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.The Journal of clinical investigation · 2009Article
- Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling.Infection and immunity · 2009Article
- Role of amphipathic helix of a herpesviral protein in membrane deformation and T cell receptor downregulation.PLoS pathogens · 2008Article
- Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Viral modulation of T-cell receptor signaling.Journal of virology · 2008Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
T cells play a central role in orchestrating immunity against pathogens, particularly viruses. Thus, impairing T cell activation is an important strategy employed by viruses to escape host immune control. The tyrosine kinase-interacting protein (Tip) of the T lymphotropic Herpesvirus saimiri (HVS) is constitutively present in lipid rafts and interacts with cellular Lck tyrosine kinase and p80 endosomal protein. Here we demonstrate that, due to the sequestration of Lck by HVS Tip, T cell receptor (TCR) stimulation fails to activate ZAP70 tyrosine kinase and to initiate downstream signaling events. TCR zeta chains in Tip-expressing T cells were initially phosphorylated to recruit ZAP70 molecule upon TCR stimulation, but the recruited ZAP70 kinase was not subsequently phosphorylated, resulting in TCR complexes that were stably associated with inactive ZAP70 kinase. Consequently, Tip expression not only markedly inhibited TCR-mediated intracellular signal transduction but also blocked TCR engagement with major histocompatibility complexes on the antigen-presenting cells and immunological synapse formation. These results demonstrate that a lymphotropic herpesvirus has evolved a novel mechanism to deregulate T cell activation to disarm host immune surveillance. This process contributes to the establishment and maintenance of viral latency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.