ArticleWorld journal of gastroenterology2004
Expression of growth hormone and its receptor in chronic atrophic gastritis and its clinical significance.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Validation of diagnostic strategies of autoimmune atrophic gastritis: A case report.World journal of clinical cases · 2021Article
- GHR is involved in gastric cell growth and apoptosis via PI3K/AKT signalling.Journal of cellular and molecular medicine · 2021Article
- Growth hormone receptor promotes osteosarcoma cell growth and metastases.FEBS open bio · 2020Article
- Growth hormone receptor expression in human primary gastric adenocarcinoma.Journal of biomedical research · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the growth hormone (GH) and growth hormone receptor (GHR) expression of and its clinical significance in patients with chronic atrophic gastritis (CAG).
methodsA total of 90 cases were enrolled in the study. Thirty were healthy controls, the other 60 patients were divided into two groups according to the endoscopical and histological diagnosis. Blood samples were drawn in the morning (menarche did not occur during the blood extraction in female patients), gastric mucosa was obtained by endoscopy. Serum GH and gastrice mucosal GHR levels were measured using radioimmunoassay (RIA) and En Vinsion technique.
resultsThe average GH level was 1.021+/-0.132 microg/L in CAG patients, in controls it was 2.869+/-0.512 microg/L. There was a significant difference between these two groups (P<0.01). The positive rate of GHR in CAG patients was 10%, in controls the rate was 100%. There was a significant difference (P<0.01). There was no significant change of GH level (3.176+/-0.421 microg/L) in patients with gastric carcinoma compared with controls (P>0.05).
conclusionThe study shows that levels of GH and GHR expression are low in CAG patients. CAG pathogenesis has a correlation with mucosal nutrient deficiency, decreased levels of GH and GHR have an adverse effect on the repair and regeneration of CAG. There is no significant change of GH in gastric carcinorma patients, GH dose not play a role in the pathogenesis of gastric cancer.
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