ArticleWorld journal of gastroenterology2004
Tumor necrosis factor alpha antibody prevents brain damage of rats with acute necrotizing pancreatitis.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research.Frontiers in physiology · 2020Pooled it
- Effects of dexmedetomidine on anesthesia recovery period and postoperative cognitive function of patients after robot-assisted laparoscopic radical cystectomy.International journal of clinical and experimental medicine · 2015Article
- Review of experimental animal models of biliary acute pancreatitis and recent advances in basic research.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2012Review
- Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis.World journal of gastroenterology · 2007Article
- Human malarial disease: a consequence of inflammatory cytokine release.Malaria journal · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the protective effects of tumor necrosis factor alpha (TNFalpha) antibody on pancreatic encephalopathy in rats.
methodsOne hundred and twenty SD rats were randomly divided into normal control group, acute necrotizing pancreatitis group and TNFalpha antibody treated group. Acute hemorrhage necrotizing pancreatitis model in rats was induced by retrograde injection of 50 g/L sodium taurocholate into the pancreatobiliary duct. Serum TNFalpha was detected and animals were killed 12 h after drug administration. Changes in content of brain water, MDA and SOD as well as leucocyte adhesion of brain microvessels were measured.
resultsIn TNFalpha antibody treated group, serum TNFalpha level was decreased. Content of brain water, MDA and SOD as well as leucocyte adhesion were decreased significantly in comparison with those of acute necrotizing pancreatitis group (P<0.05).
conclusionTNFalpha antibody can alleviate the brain damage of rats with acute hemorrhage necrotizing pancreatitis.
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Registered trials
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