ArticleWorld journal of gastroenterology2004
Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Rabeprazole suppressed gastric intestinal metaplasia through activation of GPX4-mediated ferroptosis.Frontiers in pharmacology · 2024Article
- Renoprotective effect of lansoprazole in streptozotocin-induced diabetic nephropathy in wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Effects of Pantoprazole on Systemic and Gastric Pro- and Anti-inflammatory Cytokines in Critically Ill Patients.Iranian journal of pharmaceutical research : IJPR · 2012Article
- The effects of amlodipine on the biochemical and histopathological changes in the rabbit ileum subjected to ischemia-reperfusion.The Eurasian journal of medicine · 2011Article
- Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications.Digestive diseases and sciences · 2009Review
- Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole.Journal of clinical biochemistry and nutrition · 2009Article
- The expression of heme oxygenase-1 induced by lansoprazole.Journal of clinical biochemistry and nutrition · 2009Article
- Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-alpha and Interleukin-1beta Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-kappaB and Extracellular Signal-Regulated Kinase.Journal of clinical biochemistry and nutrition · 2009Article
- Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis.Scandinavian journal of gastroenterology · 2008Article
- Anti-inflammatory and anti-oxidative properties of proton pump inhibitors.Journal of clinical biochemistry and nutrition · 2007Article
- Inflammation and oxidative stress in gastroesophageal reflux disease.Journal of clinical biochemistry and nutrition · 2007Article
- Protective effects of proton pump inhibitors against indomethacin-induced lesions in the rat small intestine.Naunyn-Schmiedeberg's archives of pharmacology · 2007Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the protective effect of lansoprazole on ischemia and reperfusion (I/R)-induced rat intestinal mucosal injury in vivo.
methodsIntestinal damage was induced by clamping both the superior mesenteric artery and the celiac trunk for 30 min followed by reperfusion in male Sprague-Dawley rats. Lansoprazole was given to rats intraperitoneally 1 h before vascular clamping.
resultsBoth the intraluminal hemoglobin and protein levels, as indices of mucosal damage, significantly increased in I/R-groups comparison with those of sham-operation groups. These increases in intraluminal hemoglobin and protein levels were significantly inhibited by the treatment with lansoprazole at a dose of 1 mg/kg. Small intestine exposed to I/R resulted in mucosal inflammation that was characterized by significant increases in thiobarbituric acid-reactive substances (TBARS), tissue-associated myeloperoxidase activity (MPO), and mucosal content of rat cytokine-induced neutrophil chemoattractant-1 (CINC-1). These increases in TBARS, MPO activities and CINC-1 content in the intestinal mucosa after I/R were all inhibited by pretreatment with lansoprazole at a dose of 1 mg/kg. Furthermore, the CINC-1 mRNA expression was increased during intestinal I/R, and this increase in mRNA expression was inhibited by treatment with lansoprazole.
conclusionLansoprazole inhibits lipid peroxidation and reduces development of intestinal mucosal inflammation induced by I/R in rats, suggesting that lansoprazole may have a therapeutic potential for I/R injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.