ArticleWorld journal of gastroenterology2004
Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Assessing the Malignant Potential of Gastric Mucosa Disorders: A Pilot Study on Lipid Peroxidation End Products and COX-2 Detection by Immunohistochemistry.Molecular carcinogenesis · 2026Article
- Aspirin Use Is Protective Against Gastric Cancer in a High-Incidence Region of Central America.Digestive diseases and sciences · 2025Article
- Linking dysbiosis to precancerous stomach through inflammation: Deeper than and beyond imaging.Frontiers in immunology · 2023Review
- Transcriptome profiling of cancer tissues in Chinese patients with gastric cancer by high-throughput sequencing.Oncology letters · 2018Article
- Article
- Clinical and prognosis relevance of COX-2 expression in Tunisian patients with primary gastric adenocarcinoma.Cancer biomarkers : section A of Disease markers · 2016Article
- Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis.World journal of gastroenterology · 2014Review
- COX-2 Inhibitors and Gastric Cancer.Gastroenterology research and practice · 2014Review
- Inhibition of 15-hydroxyprostaglandin dehydrogenase by Helicobacter pylori in human gastric carcinogenesis.Cancer prevention research (Philadelphia, Pa.) · 2013Article
- The role of PGE2-associated inflammatory responses in gastric cancer development.Seminars in immunopathology · 2013Article
- The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea.Gut and liver · 2012Article
- Cyclooxygenase-2 polymorphisms and the risk of gastric cancer in various degrees of relationship in the Chinese Han population.Oncology letters · 2012Article
- Sinomenine inhibits proliferation of SGC-7901 gastric adenocarcinoma cells via suppression of cyclooxygenase-2 expression.Oncology letters · 2011Article
- Epstein-Barr virus-specific methylation of human genes in gastric cancer cells.Infectious agents and cancer · 2010Article
- Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma.Journal of oral microbiology · 2010Article
- Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy.Molecular and cellular biochemistry · 2009Article
- Expression of COX-2 in stomach carcinogenesis.Journal of gastrointestinal cancer · 2008Article
- Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers.Journal of gastrointestinal cancer · 2007Review
- -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia.World journal of gastroenterology · 2006Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimCyclooxygenase (COX)-2 is over expressed in gastrointestinal neoplasm. Helicobacter pylori (H pylori) infection is causally linked to gastric cancer. However, the expression of COX-2 in various stages of H pylori-associated gastric carcinogenesis pathway has not been elucidated. Therefore, the aim of this study was to clarify the role of H pylori induced COX-2 expression during carcinogenesis in the stomach.
methodsGastric biopsies from 138 subjects (30 cases of chronic superficial gastritis (CSG), 28 cases of gastric glandular atrophy (GA), 45 cases of gastric mucosal intestinal metaplasia (IM), 12 cases of moderate gastric epithelial dysplasia and 23 cases of gastric cancer) were enrolled. H pylori infection was assessed by a rapid urease test and histological examination (modified Giemsa staining). The expression of COX-1 and COX-2 in human gastric mucosa was detected by immunohistochemical staining.
resultsH pylori infection rate was 64.3% in GA and 69.5% in gastric cancer, which was significantly higher than that (36.7%) in CSG (P<0.05). The positive expression rates of COX-2 were 10.0%, 35.7%, 37.8%, 41.7% and 69.5% in CSG, GA, IM, dysplasia and gastric cancer, respectively. From CSG to GA, IM, dysplasia and finally to gastric cancer, expression of COX-2 showed an ascending tendency, whereas COX-1 expression did not change significantly in the gastric mucosa. The level of COX-2 expression in IM and dysplasia was significantly higher in H pylori-positive than in H pylori-negative subjects (P<0.01).
conclusionCOX-2 expression induced by H pylori infection is a relatively early event during carcinogenesis in the stomach.
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