ArticleOncogene2004
Tumor formation in p53 mutant ovaries transplanted into wild-type female hosts.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Radiation-Associated Angiosarcoma of the Breast: The State of the Art of a Rare and Aggressive Disease.Journal of personalized medicine · 2024Review
- Angiosarcoma of the Breast: Overview of Current Data and Multimodal Imaging Findings.Journal of imaging · 2023Review
- Angiosarcoma of the breast, the unknown-a review of the current literature.Translational cancer research · 2019Review
- Defective Nuclear Lamina in Aneuploidy and Carcinogenesis.Frontiers in oncology · 2018Review
- Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis.BMC cell biology · 2016Article
- Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis.Molecular and cellular biology · 2016Article
- Development of a mouse model of menopausal ovarian cancer.Frontiers in oncology · 2014Review
- Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- An absence of Twist1 results in aberrant cardiac neural crest morphogenesis.Developmental biology · 2008Article
- Article
- A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.The American journal of pathology · 2007Article
- Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background.The American journal of pathology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
P53: gene alterations correlate highly with advanced ovarian carcinoma in women. In mice, p53 deficiency predominantly results in the formation of lymphomas and sarcomas. However, ovarian epithelial tumors have not been documented in p53 homozygous mutant (p53-/-) mice, probably because they die before other tumors can form. To determine whether p53-/- ovaries can develop epithelial tumors, they were transplanted into the ovarian bursae of histocompatible wild-type recipient females. The p53-/- ovarian grafts formed tumors approximately 1 year post-transplantation. The tumor type was angiosarcoma, suggesting that vascular tissues are predisposed to tumor formation in p53-/-ovaries. These findings suggest that p53 deficiency alone is not sufficient for ovarian epithelial tumorigenesis in mice. Thus, other genetic lesions are likely required to develop mouse models of human ovarian cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.