ArticleImmunology1992
Trypanosoma cruzi suppresses the expression of the p75 chain of interleukin-2 receptors on the surface of activated helper and cytotoxic human lymphocytes.
Article in Immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- GRAIL and Otubain-1 are Related to T Cell Hyporesponsiveness during Trypanosoma cruzi Infection.PLoS neglected tropical diseases · 2017Article
- Decreased level of antibodies and cardiac involvement in patients with chronic Chagas heart disease vaccinated with BCG.Medical microbiology and immunology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
When Trypanosoma cruzi is co-cultured with activated human lymphocytes the latter manifest a marked level of suppression in their capacity to express high-affinity interleukin-2 receptors (IL-2R). In this study we asked whether this effect could result from reduced expression of the p75 component of the IL-2R, a condition which would limit the number of heterodimeric receptors that could be assembled by activated T cells. The results of two-colour flow cytometric analyses revealed that both the percentage and surface density of p75 molecules on phytohaemagglutinin-stimulated CD3+, CD4+ or CD8+ lymphocytes were significantly reduced in the presence of T. cruzi, whether or not the parasites were separated from the lymphocytes by a cell-impermeable filter. These results suggested that reduced expression of p75 chains would limit the number of IL-2R assembled by activated T lymphocytes, contributing in this manner to the immunosuppression that occurs during acute T. cruzi infection.
Indexed as
Identifiers
1533390PMC1384753W2417970933What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.